Sbarro Health Research Organization

02/24/2026

Ever heard of CDK10? It's a key enzyme that regulates the cell cycle.

Why does it matter? In endometrial cancer, the most common gynecological cancer among women in the West, CDK10 plays a starring role.

Targeting this enzyme offers strong potential as a key focus for future therapies.

At the Sbarro Institute, our researchers are actively studying CDK10's potential.

Stay tuned!

02/23/2026

One Health isn’t an abstract theory or a slogan.

It’s a different way of doing prevention.

It means recognizing that many diseases don’t originate in the doctor’s office, but much earlier: in farms, food supply chains, antibiotic use, pollution, and our lifestyles.

Read more 👇🏼

One Health: The health of humans, animals, and the environment is closely interconnected. They're parts of the same system.

02/20/2026

Our body has a natural defense mechanism that triggers a real “fire alarm” and shuts down the replication of tumor cells.

It’s p53, the guardian of the genome.

A special protein that detects damage in cells and puts them “to sleep” by activating cellular senescence.

The cell doesn’t die—it’s still active, but stops replicating.

Swipe through the carousel to discover why understanding p53 is key to developing personalized therapies and prevention strategies.

02/18/2026

The heart isn’t just the muscle responsible for pumping blood: it’s a fascinating organ marked by surprising biological complexity.
Recent studies suggest it has adopted an extreme evolutionary strategy to ensure its survival.

New article written by Professor Antonio Giordano

The Heart - An enigmatic organ that communicates with us, influences our emotions, pain perception, and level of calm.

02/17/2026

Research doesn’t just happen in labs: it lives in people’s stories, in the daily questions we ask about health and the future.

At SHRO – Sbarro Health Research Organization – we’ve dedicated years to cancer research, with over 1,000 scientific publications and training programs.

We’re taking you behind the scenes of research: what prevention really means, what oncology research entails, how discoveries are made, which habits truly make a difference, plus the faces of our scientific community and stories of those who’ve benefited from our work.

Science belongs to everyone – if everyone can understand it.

Follow us, ask questions in the comments, and share this content with those who need it.
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12/31/2025

Cosa ci riserverà il 2026? Una riflessione e un augurio per il nuovo anno dal Presidente della Fondazione SHRO, Prof. Antonio Giordano.

🇺🇸 What does 2026 have in store for us? A perspective and a New Year’s message from Professor Antonio Giordano, President of the SHRO Foundation.

12/25/2025

✨🎄 Merry Christmas and a Happy 2026! 🎄✨
May this festive season bring peace, joy, and new dreams to pursue.
Through the commitment of scientific research, we continue to work every day to prevent and treat serious diseases, improve quality of life, and promote greater longevity for all.
Thank you for your trust, support, and collaboration throughout the year.
See you in 2026, ready to build new opportunities together! ✨🎁

Antonio Giordano
President
Sbarro Health Research Organization

11/10/2025

We join Dr. Antonio Giordano and the Sbarro Health Research Organization (SHRO) in honoring the remarkable legacy of Dr. James D. Watson, a visionary scientist whose discovery of the DNA double helix forever changed the world of genetics. 🧬

As Dr. Giordano beautifully reflects, Dr. Watson’s pioneering spirit, mentorship, and dedication to science continue to inspire new generations of researchers to push the boundaries of discovery.

At SHRO, we remain committed to advancing this legacy — fostering innovation, collaboration, and mentorship in biomedical research worldwide. 🌍

Read the article on newswise 👉

https://lnkd.in/gyj26CJ4

10/09/2025

🌟 Congratulations to the winners of the 2025 Nobel Prize in Physiology or Medicine!

On behalf of the Sbarro Health Research Organization – SHRO Italy, we congratulate Mary E. Brunkow, Frederick J. (Fred) Ramsdell, and Shimon Sakaguchi, awarded the Nobel Prize “for discoveries on peripheral immune tolerance” and on the role of regulatory T cells (Tregs) in keeping the immune system in balance.

Thanks to these discoveries, oncologists have: gained a better understanding of how tumors “switch off” the immune system through Tregs that suppress anti-cancer responses; developed strategies to bypass or block this brake; introduced new biomarkers — including FOXP3 — to identify patients with a highly immunosuppressive tumor microenvironment and to guide therapeutic decisions.

In short, this knowledge has made immuno-oncology therapies more personalized and effective.

As an Italian–American organization committed to translational research, SHRO renews its commitment to transforming basic discoveries into tangible benefits for patients, training young researchers, and strengthening collaborations between Italy and the USA.

Congratulations to the 2025 Nobel laureates, and thanks to the scientific community that builds progress every day.

Read more: https://shro.org/shros-congrats-to-the-winners-of-the-2025-nobel-prize-in-physiology-or-medicine/

09/16/2025

The team demonstrated that Castalin can boost the effectiveness of CHK1 inhibitors, a class of drugs currently in phase 1 clinical trials.

“This discovery is part of a larger project focused on identifying new natural molecules that can be used in cancer treatment,” says Dr. Luigi Alfano, head of the research group behind the study, who collaborated with Prof. Forino and Prof. Frusciante from the Department of Agriculture at Federico II University of Naples.

According to Prof. Antonio Giordano, director of the Sbarro Institute, “This breakthrough opens new possibilities in the fight against cancer and shows how our idea of turning to nature as a source of new molecules is truly paying off.”

The implications are especially promising for triple-negative breast cancer.

“Our next goal is to explore the potential clinical applications of Castalin in breast cancer, both as a stand-alone treatment and in combination with the latest chemotherapy drugs,” adds Prof. Michelino de Laurentiis, director of the Thoracic and Pulmonary Department at the Pascale Cancer Institute in Naples.

Temple University College of Science and Technology at Temple University Scuola Superiore Meridionale

Scientists identified a natural extract that could help boost the effectiveness of cancer drugs. The insights gained from their study...

09/12/2025

💕 Today we honor the 100th anniversary of Giovan Giacomo Giordano (1925–2010) a Naples-born pathologist who united science, ethics and civic responsibility.

For over fifty years he trained generations of physicians, introducing in Italy the use of monoclonal antibodies and molecular biology in cancer diagnostics, opening the way to precision medicine. He also raised an early alarm on the link between environmental pollution and cancer (“Health and Environment in Campania”), and stood firmly for integrity in public healthcare. His guiding lesson endures: “First be a person, then a person of science.”

In this interview Professor Antonio Giordano reflects on his father’s legacy: science at the service of people, with rigor and responsibility.

👉 Read the interview on Informareonline.
https://informareonline.com/cento-anni-di-giovan-giacomo-giordano-il-ricordo-del-professor-antonio-giordano/

09/02/2025

🔴 Applications open: Brain Circulation 2025/26, Translational Gynecology Fellowship.

For future leaders in women’s health, a hands-on journey across Cremona, Philadelphia, Gaithersburg and New York, covering surgical anatomy, AI and molecular medicine, biotech and clinical translation, from Dec 2025 to Nov 2026.

Benefits include full fellowship training, a funded project, elite mentorship and high-impact visibility.

Deadline: October 3, 2025. Apply with a single PDF.

🗣 Tag a colleague who should apply.

See more and download the application form👇
https://shro.org/call-for-applications/