02/16/2026
đź§ Clinical Research Update from Jefferson Neurosurgery
On December 12, 2025, Dr. Chengyuan Wu, in collaboration with Dr. Mijail Serruya, treated the first patient at Jefferson Neurosurgery as part of the Enspire RESTORE DBS Clinical Trial. This investigational research study is evaluating whether Deep Brain Stimulation (DBS) combined with rehabilitation may serve as a possible new treatment approach to improve upper-extremity function in individuals living with chronic stroke-related impairment.
The trial builds on encouraging findings from a Phase I study conducted at Cleveland Clinic, which demonstrated that DBS paired with rehabilitation in 12 patients was feasible and showed promising signals of motor improvement in patients with chronic stroke deficits. RESTORE now aims to further evaluate safety and explore potential effectiveness in a broader cohort. The RESTORE trial is designed to further assess the safety and potential effectiveness of this approach. Participation contributes to ongoing research exploring additional options for stroke recovery.
Learn more about the innovative work behind this effort at enspiredbs.com Enspire DBS Therapy and the RESTORE stroke study.
đź“© Interested in more info or joining the study?
Email: neurosurgeryresearch@jefferson.edu
📞 Call: Danna at 610-425-0746
https://neurorestoration.jefferson.edu/programs-clinical-trials/restore.html