02/05/2026
Benadryl (Diphenhydramine) Overdose Education
Know the Risks. Spot the Signs. Keep Kids Safe.
Diphenhydramine is a common OTC allergy medication (often known by the brand name Benadryl). While safe when used as directed, taking too much can be life-threatening.
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π What is the "Benadryl Challenge"?
The FDA has issued warnings about a dangerous trend on social media (specifically TikTok) where teenagers are encouraged to take excessive doses of Benadryl to induce hallucinations.
β’ The Reality: There is no "safe" high. High doses cause hallucinations, seizures, heart problems, coma, and death.
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π Symptoms of Overdose
Symptoms typically appear within 1-2 hours of ingestion.
β’ Severe Drowsiness/Sedation
β’ Agitation or Excitement
β’ Hallucinations or Confusion
β’ Dilated Pupils
β’ Dry Mouth & Flushed Skin
β’ Rapid Heartbeat (Tachycardia)
β’ Seizures
β’ Inability to urinate
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π What to Do in an Emergency
If you suspect a Benadryl overdose, do not wait for symptoms to worsen.
1. Call 911 immediately if the person is:
1. Not waking up
2. Having a seizure
3. Having trouble breathing
2. Call Poison Control at 1-800-222-1222 (available 24/7, free and confidential).
3. Stay with the person and monitor their breathing.
4. Find the medication and bring the bottle to the emergency room.
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π‘οΈ Prevention & Safety Tips
β’ Lock it up: Keep all OTC and prescription medicines up, away, and out of sight of children and teens.
β’ Read the Label: Always follow the dosage instructions on the package. Do not take more than directed.
β’ Check Ingredients: Do not mix Benadryl with other cold or "PM" sleep medicines, as they may already contain diphenhydramine, leading to an accidental overdose.
β’ Talk to Teens: Educate teenagers that OTC medication is not harmless and misuse can have severe consequences.
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For more information, contact the National Poison Help hotline: 1-800-222-1222
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Source Material: FDA Drug Safety Communication (Sept 2020), Missouri Poison Center, StatPearls (NCBI), Upstate New York Poison Center.