RxKinetics

12/25/2025

New blog post

AI Santa Claus Posted on December 25, 2025 by tharpr Lately, I’ve been diving into the world of artificial intelligence. I had been refusing to participate in what I perceived as nonsense. My day began, like many, with a bit of doom-scrolling through Reddit to see what fresh chaos the current admi...

10/19/2025

New blog post:

Windows 11 = Privacy Nightmare and E-Waste Disaster Posted on October 19, 2025 by tharpr Windows 10 support officially ended this week. Just kidding. But you have to sign up for another year of free security updates. Go to Settings -> Update & Security. There you’ll (hopefully) see a link to enrol...

06/25/2025

New blog post

APK 3.5.30 update Posted on June 25, 2025 by tharpr Yes, it’s been a while. I suppose I’m from the old school who believe “if it ain’t broke, don’t fix it”. This 30th update of version 3.5 adds a few new security features and an import function. Strong password option There are risks ass...

10/22/2021

https://rxkinetics.com/blog/?p=1766

Doors of perception Posted on October 22, 2021 by tharpr Reviewing my search console report today I found the most linked page on my web site is my review of AUC guided dosing of vancomycin. In the top linked text section I found “how precisepk helps pharmacist compliance”. So naturally I pulled...

10/20/2021

SSL only

SSL only Posted on October 20, 2021 by tharpr Reply To make google happy and to stop them from lying about the safety of my website I’ve forced https re-direct on the RxKinetics website. I’ve put it off because of the hassle it will cause every visitor here. And I resent the fact that google has...

06/04/2021

Hello Rick, We tested your program and we really like it. Nice work on APK.
Kind regards, Carlos - SPAIN

06/04/2021

Thanks a lot for your help, and -again- for your software. It will be a tremendous help for all our patients in treatment with vanco, cefepime and aminoglycosides. Have a nice afternoon, from CHILE.

05/03/2021

http://rxkinetics.com/blog/?p=1747

Antibiotic Kinetics Update Posted on May 3, 2021 by tharpr This update was long overdue. It has been nearly two years since the last significant update and a lot has changed since then. I’ve been on a sabbatical of sorts from programming since last summer when I retired from the full-time hospital...

12/08/2019

http://rxkinetics.com/blog/?p=1724

03/29/2019

http://rxkinetics.com/blog/?p=1687

02/09/2018

Analysis of Targeted AUC Dosing Posted on February 8, 2018 by tharpr Evidence regarding vancomycin pharmacokinetics/pharmacodynamics has initiated a paradigm shift in vancomycin dosing from targeting trough concentrations to area under the concentration-time curve (AUC). Although clinical data sugge...

02/02/2018

Targeted AUC Dosing Posted on February 2, 2018 by tharpr The 24-hr AUC/MIC ratio The trough level is but a surrogate marker for the true pharmacodynamic parameter for vancomcyin, the 24-hr AUC/MIC ratio. The target vancomycin trough level of 15-20 mg/liter was chosen in the 2009 vancomycin TDM guide...