Calyxo, Inc.

02/26/2026

New evidence reinforces a new, patient-centered standard for assessing efficacy of stone removal procedures. The Journal of Endourology recently published results from the CLEARANCE study and ASPIRE randomized controlled trial evaluating the CVAC System.

Key findings include:
• 96% mean stone clearance and very low residual stone volume (14.1 mm³)(1)
• 73% reduction in unplanned healthcare events* compared with standard ureteroscopy(2)
• Residual stone volume, not stone-free rate, was a predictor of long-term outcomes

These findings reinforce the importance of minimizing residual stone burden to improve meaningful, long-term patient outcomes.

Read the full release: https://calyxoinc.com/calyxo-news/cvac-system-reduces-residual-stone-volume-unplanned-health-events/

*ED visits, hospitalizations, and retreatments likely due to residual stones at the end of the procedure

References:
1 Eisner BH, et al. J Endourology. 2026.
2.Matlaga BR, et al. J Endourology. 2026.

Learn more about the : https://calyxoinc.com

Safety Info: https://calyxoinc.com/isi

02/25/2026

🌟What an achievement!

Congratulations to Center For Urology in Rochester, NY on collectively completing 600 procedures.

This milestone was made possible by these five physicians, their partners, and the entire Center of Urology team:
Alexander Cranwell, M.D.
Sameer Farooq, M.D.
Anees Fazili, M.D.
Matthew Truong, M.D.
Patrick Vecellio, M.D.

🚀 Thank you for your continued commitment to advancing innovation in and improving patient care.

Learn more about the at: https://calyxoinc.com

Safety Info: https://calyxoinc.com/isi

02/19/2026

🥇 First case complete!

Congratulations to Drs. Timothy Langford and Jack Massey of University of Arkansas for Medical Sciences on achieving this milestone! Their use of this cutting-edge technology is helping improve the lives of patients with kidney stones. 👏

Learn more about the at: https://calyxoinc.com

Safety Info: https://calyxoinc.com/isi

02/05/2026

🎉 Huge milestone! Congratulations to Dr. Ryan Sidebottom of Upstate Urology on completing his 50th at Auburn Community Hospital in Auburn, New York. Achieving a 99% stone clearance for a 15 mm stone is a testament to their expertise and the power of innovation in .

Learn more about Calyxo: https://calyxoinc.com/calyxo-cvac-system/

Safety Info: https://calyxoinc.com/isi/

10/29/2025

In case you didn’t know: Not all suction is aspiration!

The was up to 80x superior in aspiration across all stone sizes when compared to DISS 7.5Fr. 👏

Don’t believe the data? See it for yourself:

Reference
Johnson, Brett A., et al. EAU 2025.

Learn more about the CVAC System at: https://calyxoinc.com

Safety Info: https://calyxoinc.com/isi

10/22/2025

📊The numbers tell the story.

Even with 3x more pre-op stone volume, the cleared more stones than FANS in similar procedure times.

The verdict is clear: CVAC System outperforms FANS on efficiency.

Reference
Cabo et al. WCET 2025.

Learn more about the CVAC System at: https://calyxoinc.com

Safety Info: https://calyxoinc.com/isi

10/15/2025

With the , stone size doesn’t compromise outcomes. 💡

Calyxo’s CVAC System results in low residual stone volume (RSV) regardless of baseline stone burden, while FANS - which is similar to basketing during ureteroscopy - leaves behind more RSV with an increasing baseline stone burden.

The main takeaway: With the CVAC System, RSV remains low regardless of baseline stone volume. 👏

Reference
Cabo et al. WCET 2025.

Learn more about the CVAC System at: https://calyxoinc.com

Safety Info: https://calyxoinc.com/isi

10/10/2025

🎉 Join us in welcoming to the newest members to the community!​

We’re thrilled to grow across our Sales, Professional Education, Marketing, and Regulatory teams. We can’t wait to see the talent you will bring to our mission: transforming the future of kidney stone care.​

Welcome to the team!​

Learn more about the at: https://calyxoinc.com ​

Safety Info: https://calyxoinc.com/isi ​

10/09/2025

⭐We’re advancing the conversation as a co-sponsor of the upcoming Mary Ann Liebert Webinar, Emerging Aspiration Technologies in Ureteroscopy: Enhancing Stone Clearance and Safety

🗓️Tuesday, Oct 14, 2025 | 7:00 PM ET / 4:00 PM PT

Hear from experts on the evolving role of aspiration and suction in ureteroscopy, practical tips for optimizing outcomes, and real-world insights you can bring to your practice.

🔗 Register today: https://home.liebertpub.com/lpages/end-calyxo-dornier-webinar-emerging-aspiration-technologies-in-ureteroscopy/428

Learn more about the CVAC System at: https://calyxoinc.com

Safety Info: https://calyxoinc.com/isi

10/06/2025

Congratulations to Dr. Rudolph Bowens, MD, who successfully completed the first case at St. Bernard’s Regional Medical Center!👏​

Dr. Bowens achieved an impressive 99% stone clearance for an 11 mm stone located in the lower pole, demonstrating the power of innovation in urology and advancing patient care.​

Learn more about the at: https://calyxoinc.com ​

Safety Info: https://calyxoinc.com/isi​

09/30/2025

The is redefining kidney stone treatment and Dr. Joseph Song discussed its impact with Urology Times.

“I think it's something that's shown a lot of promise. I suspect it's going to transform the way a lot of us do ureteroscopy and also transform some of the outcomes our patients are going to see.”

🔗📰 Watch the full interview here: sqr.co/iwcq/

Learn more about the at: https://calyxoinc.com

Safety Info: https://calyxoinc.com/isi

09/29/2025

In an interview with Urology Times, Margaret Knoedler, MD, discusses her experience using the new CVAC System with Reverse Deflection and highlights the benefits of the different modes for both surgeons and trainees. 👏

See the interview here:
📰 https://www.urologytimes.com/view/margaret-knoedler-md-on-the-reverse-deflection-cvac-system

Learn more about the CVAC System at: https://calyxoinc.com

Safety Info: https://calyxoinc.com/isi

Margaret A. Knoedler, MD, discusses her experience using the Reverse Deflection CVAC System.