04/03/2026
Our paper of the month for April is "Effects of Levodopa on Gait in People With Parkinson’s Disease With and Without a History of Falls" by Martina Mancini, Patty Carlson-Kuhta, Jay Nutt, Fay Horak, and Vrutangkumar Shah.
The impact of levodopa on gait in individuals with Parkinson's disease (PD), particularly in those with and without a history of falls, remains unclear. This study examines whether levodopa alters digital gait characteristics in fallers and non-fallers with PD to those observed in healthy controls (HC) and identifies key gait and turning measures most influenced by levodopa. The findings suggest that impaired turning and gait shuffling in PD may be associated with falls and that dopamine replacement therapy, as well as rehabilitation, focused on improving turning and gait shuffling may reduce fall risk.
https://movementdisorders.onlinelibrary.wiley.com/doi/pdf/10.1002/mdc3.70330