09/17/2025
🎤 30th Annual Conference Speaker Highlight 🎤
We’re excited to welcome Bradley Bush, ND to our speaker lineup!
🎙 "Pharmaceutical Interventions for Tough SIBO Cases"
📚 1 Pharm CE Hour - RECORDED
Learn more below and register today at www.oanp.org/annual-conference
Bio: Bradley Bush, ND, is a naturopathic doctor who graduated from NCNM (now National University of Naturopathic Medicine) in Portland, OR. He is the owner and Clinic Director of Natural Medicine of Stillwater and the breath testing lab, Neurovanna, both based in Stillwater, MN. Additionally, Dr. Bradley is Chief Medical Officer for the Endurance Products Company (Tulatin, OR). Dr. Bush specializes in gastrointestinal health, mood disorders, neuro-endocrine conditions, insomnia, infections, and autoimmune diseases. Residing in Stillwater with his naturopathic doctor wife and four daughters, he enjoys cooking and gardening in his free time.
Abstract: Managing Small Intestinal Bacterial Overgrowth (SIBO) can be particularly challenging when patients fail to respond to dietary strategies, herbal antimicrobials, or standard pharmaceutical regimens. This presentation focuses on pharmacological interventions for complex or relapsing SIBO cases, with an emphasis on mechanism-based prescribing, emerging off-label strategies, and patient-specific customization. Attendees will receive a comprehensive review of FDA-approved and off-label pharmaceuticals used in SIBO treatment, including Rifaximin, Neomycin, and Metronidazole, with comparisons of efficacy, safety, and common protocols. We will also explore how low-dose erythromycin may support motility restoration and prevent relapse through its prokinetic properties. For more refractory or systemic presentations, the session will highlight the use of Low Dose Naltrexone (LDN) for immune modulation and cromolyn sodium or ketotifen in cases with mast cell activation or histamine-driven gut dysregulation. Additionally, emerging anti-parasitic options such as nitazoxanide and ivermectin will be discussed in the context of methane-SIBO, protozoal overgrowth, and difficult-to-eradicate microbial biofilms.