02/19/2026
I woke up this morning and my heart is happy.
Clinicians across the country are posting about the framework I presented on last night, hosted by Clinicians are asking about “terrain” when it comes to PRP injections. They’re talking about hormone receptors in MSK tissue.
THIS IS SUCH AN IMPORTANT CONVERSATION IN PAIN AND MSK INTERVENTIONS.
We don’t have all the answers yet. But here’s what we DO know:
1) Estrogen, progesterone and testosterone receptors exist in bones, tendons, ligaments, cartilage
2) Growth factor signaling (TGF-beta, IGF-1) is hormone-dependent
3) 70% of menopausal women report joint pain and 40% have NO structural findings on imaging
4) 99% of preclinical aging studies ignore menopause (Nature Aging, 2024), including those looking at PRP
So why WOULDN’T we question or consider hormonal terrain before—or alongside—PRP?
The terrain model isn’t just a metaphor. It’s a call to revolutionize how we approach regenerative medicine for women (and men with changing hormones, too).
To every clinician interested in these questions: THANK YOU. Keep going. Our patients need us to think differently. I am so excited to see where this conversation takes us.
What questions do you have about hormonal terrain and regenerative medicine? Drop them below. 👇