01/29/2026
Albumin and prealbumin are often misunderstood—and frequently misused—when assessing wound healing potential ❗️
🔬 Albumin
• Reflects chronic illness, inflammation, fluid status, and liver function
• If the liver is stressed or failing, albumin production may drop—even when nutrition is adequate ⚠️
• With a long half-life (~18–21 days), albumin does not reflect current protein intake or short-term nutritional changes
• 🚫 Should not be used alone to judge wound healing readiness
🧬 Prealbumin (Transthyretin)
• Much shorter half-life (~48–72 hours) ⏱️
• More responsive to recent nutritional changes, making it helpful for trending short-term interventions
• Still affected by inflammation, infection, and acute illness—just like albumin 🦠
🔥 CRP Overlay Matters
• Always interpret albumin and prealbumin alongside CRP
• Inflammation suppresses both labs regardless of nutritional intake 📉
💡 Pearl Takeaway
Neither albumin nor prealbumin predicts wound healing on their own.
They help identify physiologic and nutritional barriers, not healing guarantees.
👉 Always interpret labs in clinical context, alongside inflammation, organ function, and the patient’s overall condition 🧠🩺
PamelaScarborough,PT,DPT,CWS,FAAWC