11/18/2025
So you’re in perimenopause and we’re thinking about treating with hormone therapy, but:
1. What do we do about the periods?
2. How do we prevent pregnancy?
A good perimenopause hormone therapy plan must manage periods and ensure reliable contraception—if pregnancy is a risk.
If pregnancy is a possibility, a progesterone-containing IUD (Mirena or Liletta are best) plus systemic estrogen is an excellent solution. The IUD keeps the uterine lining thin—meaning light or absent periods—while estrogen manages symptoms. Another strategy is Slynd (a progesterone-only pill) taken daily, plus an estrogen product. And of course, combined hormonal birth control pills can provide both reliable contraception and stable daily hormones to keep the perimenopause chaos in check.