02/12/2026
A question clinicians get asked a lot is "why do some antidepressants work and not others?" This is an excellent question, and the short answer is "we don't know."
We also often get asked "which antidepressant is the most effective?" Interestingly, all of the antidepressants have roughly the same level of efficacy. In other words, if you take 100 random patients and put them on any one of the antidepressants, you will see roughly the same percent of patients h...