Medical Laboratory Science Program - Mayo Clinic

Medical Laboratory Science Program - Mayo Clinic The Mayo Clinic Medical Laboratory Science Program is housed in our renowned Department of Laboratory Medicine and Pathology.

Medical laboratory scientists are medical professionals that develop, perform and troubleshoot the assays and methods for analysis of blood, tissue and body fluids in diagnostic laboratories.According to some experts, approximately 70 percent of the objective information that physicians and other health care providers use to make medical decisions comes from the clinical laboratory. Laboratory testing is used for diagnosis, prognosis or risk determination, and monitoring of therapy. A medical laboratory scientist must have a broad background in clinical biochemistry, microbiology, immunohematology (transfusion medicine), hematology and coagulation, and molecular diagnostics to function in today's modern diagnostic laboratory. Concepts in laboratory management, regulation and accreditation, and statistical concepts are also of fundamental importance. Additionally, once training is complete, students may choose to specialize in a particular area of diagnostics, such as molecular diagnostics, coagulation, hematology and microbiology. Not only do our students learn from our distinguished medical and allied health staff instructors, but we have also implemented progressive teaching strategies that incorporate online learning and make the most of our student's educational experience. The program gives students access to numerous specialized, cutting-edge diagnostic laboratories for training that allow them to get a head start on finding areas of special interest (for those who choose to focus on specific areas of testing after training). Our core laboratories also provide an outstanding training area for students interested in generalist positions after graduation.Our unique quality control course combines an online component offered by a world-renowned quality control expert (James Westgard) combined with in-class hands-on activities to reinforce concepts and teach day-to-day application. Medical laboratory scientists are in great demand and are highly sought after by clinical laboratories here and across the country, and the forecast for job opportunities remains excellent. Our program prepares students for a career in one of the most rewarding and fastest growing areas in health care — medical laboratory diagnostics.

The Fertility Testing (Andrology) Laboratory provides both analytical testing and clinical services for patients at Mayo...
03/17/2026

The Fertility Testing (Andrology) Laboratory provides both analytical testing and clinical services for patients at Mayo Clinic, as well as for outside clients through Mayo Clinic Laboratories. The lab performs a variety of tests to assess male fertility, including semen analysis, post‑vasectomy analysis, and detailed evaluation of s***m morphology. Clinical services include s***m preparation for intrauterine and therapeutic donor inseminations, as well as semen cryopreservation.

This week, MLS student Allyssa is rotating through the Fertility Testing Laboratory and gaining hands‑on experience with these specialized procedures. She is learning how to retrieve frozen patient specimens from the ultra‑cold storage tank for thawing prior to intrauterine insemination (IUI), examine post‑vasectomy specimens at the microscope to assess for live s***m, and carefully pipette specimens onto slides for microscopic review while working in a laminar flow hood.

Last week, MLS student Catie spent time in the Clinical Microbiology Molecular Laboratory (CMML). During her rotation, s...
03/16/2026

Last week, MLS student Catie spent time in the Clinical Microbiology Molecular Laboratory (CMML). During her rotation, she gained hands-on experience handling unidentified specimens inside the biological safety cabinet and learned how to operate the Janus Automated Pipetter.
Both of these skills are key steps in preparing samples for PCR extraction and testing—great practice for real-world molecular diagnostics!

Our Molecular Technologies Laboratory at Mayo provides expertise in DNA/molecular genetic testing for both congenital di...
03/15/2026

Our Molecular Technologies Laboratory at Mayo provides expertise in DNA/molecular genetic testing for both congenital disorders and oncology. This past week, MLS student Rhiannon rotated through the lab and had the chance to practice scraping slides for DNA extraction.

Each day during their clinical experience, our MLS Transfusion Medicine students attend Morning Conference. This is an e...
03/13/2026

Each day during their clinical experience, our MLS Transfusion Medicine students attend Morning Conference. This is an excellent opportunity for them to interact with consultants, residents, fellows, and other technologists through interprofessional education. MLS student Jake volunteered to present the first two serology workups on Wednesday, joining Dr. Eggink, our current Pathology Resident on Transfusion, and our consultant of the day, Dr. Lu, at the table.

MLS student Ashley is spending the week in the Infectious Diseases Serology Laboratory, where the team specializes in an...
03/11/2026

MLS student Ashley is spending the week in the Infectious Diseases Serology Laboratory, where the team specializes in antibody and antigen testing on a wide range of body fluid specimens from clients around the world. The lab uses an array of methodologies—ELISA, IFA, Immunoblot, Complement Fixation, Immunodiffusion, Multiplex Flow, Lateral Flow, and Agglutination—to support infectious disease diagnosis. Ashley is pictured learning how to load and read immunodiffusion plates.

MLS student Katie is diving into ABO/Rh discrepancy resolution this week!During her Transfusion Medicine clinical experi...
03/09/2026

MLS student Katie is diving into ABO/Rh discrepancy resolution this week!
During her Transfusion Medicine clinical experience, she’s evaluating potential causes for unexpected results and performing the necessary follow‑up testing to pinpoint—and resolve—those discrepancies. Great work, Katie!

MLS student Laura spent time in the Molecular Technologies Lab last week, where she learned how to load samples onto a d...
03/08/2026

MLS student Laura spent time in the Molecular Technologies Lab last week, where she learned how to load samples onto a droplet generator for a droplet digital PCR assay.

MLS student Sydney spent the week rotating through the Metals Laboratory, where she had the opportunity to suit up in a ...
03/06/2026

MLS student Sydney spent the week rotating through the Metals Laboratory, where she had the opportunity to suit up in a Tyvek gown and hair cover to work in the ISO 7 cleanroom environment. During her rotation, she performed kidney stone analysis, completed selenium blood assays, conducted lead and heavy metal screening, and gained hands‑on experience with routine instrument maintenance.

MLS student Laura worked on the HPLC bench in the Metabolic Hematology Laboratory this week.  During this bench experien...
03/04/2026

MLS student Laura worked on the HPLC bench in the Metabolic Hematology Laboratory this week. During this bench experience, she analyzed specimens for quality issues such as labeling errors, hemolysis, or short volume before loading the racks onto the HPLC analyzer. After results were generated, Laura learned how to examine the chromatogram, focusing on peak areas, retention times, and overall pattern to determine if any reflex testing was needed.

MLS student Jenna was suited up in a powered air‑purifying respirator (PAPR) last week as she worked in the Biosafety Le...
03/02/2026

MLS student Jenna was suited up in a powered air‑purifying respirator (PAPR) last week as she worked in the Biosafety Level 3 area in the Mycology Laboratory with instructor Mara. She prepared tape mounts of filamentous fungi to visualize their structures and identified them under the microscope.

This week brought a new cohort of Transfusion Medicine students to the Stabile 3-50 teaching lab. During a laboratory le...
02/27/2026

This week brought a new cohort of Transfusion Medicine students to the Stabile 3-50 teaching lab. During a laboratory lesson MLS student A***n presented his detailed mind map outlining the many potential causes of quality control failures in the Blood Bank. Great analytical thinking A***n!

This past week, MLS student Marguerite completed her rotation in the Hospital Clinical Laboratory, spending time on the ...
02/25/2026

This past week, MLS student Marguerite completed her rotation in the Hospital Clinical Laboratory, spending time on the molecular bench where she processed nasopharyngeal swabs for SARS‑CoV‑2, RSV, and Influenza A/B testing. After clipping the metal portion of each swab into the media tube, she transferred the sample into rapid PCR cartridges and loaded them onto the Roche Liat analyzer for testing.

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