01/27/2026
A CNL 2025 Wrap – a year in the life of our lab:
In 2025, our work advanced understanding of how the brain integrates, prioritizes, and adapts to sensory information across health and disease. Across human neurophysiology, computational modeling, clinical trials, animal models, and large-scale health records, we showed how multisensory signals dynamically interact to shape perception, decision-making, and action. Several studies identified altered neural encoding of sensory and speech signals in autism, spanning basic somatosensation, naturalistic audiovisual speech, and real-world behavior. Complementary work clarified mechanisms of multisensory accumulation, competition, and intersensory switching in typical brains. We also linked sensory dysfunction to developmental and disease processes, from Batten disease progression in mice to post-acute COVID sequelae and intervention outcomes in autistic children, highlighting translational and societal relevance.
1. Vanneau, T., Quiquempoix, M., Foxe, J.J., Molholm, S. Neural Mechanisms of Intersensory Switching: Evidence for Delayed Sensory Processing and Increased Cognitive Demands. NeuroImage, 2025, 309: 121089.
2. Egan, J., Gomez-Ramirez, M., Foxe, J.J., O’Connell, R., Kelly, S.P. Distinct audio and visual accumulators coactivate motor preparation for multisensory detection. Nature Human Behaviour, 2025, in press.
3. Isenstein, E.L., Freedman, E.G., Rico, G.A., Brown, Z., Tadin, D., Foxe, J.J. Adults on the autism spectrum differ from neurotypical peers when self-generating but not passively-experiencing somatosensation: a high-density electrophysiological (EEG) mapping and virtual reality study. NeuroImage, 2025, 311: 121215.
4. Vanneau, T., Crosse. M.J., Foxe, J.J., Molholm, S. Impaired neural encoding of naturalistic audiovisual speech in autism. NeuroImage, 2025, 318: 121397.
5. Schaaf, R.C., Ridgway, E.M., Jones, E., Dumont, R.L., Foxe, J.J., Conly, T., Sancimino, C., Yi, M., Mailloux, Z., Hunt, J.M., Kirschner, L., Leiby, B.E., Molholm, S. A Comparative Trial of Occupational Therapy using Ayres Sensory Integration® and Applied Behavior Analysis Interventions for Autistic Children. Autism Research, 2025, 18(10): 2120-2134.
6. Monti, M., Molholm, S., Foxe, J.J., Cuppini, C. Is competition the default configuration of cross-sensory interactions? European Journal of Neuroscience, 2025, 62(4): e70233.
7. Ding, Y., Feng, J., Prifti, V., Rico, G., Solorzano, A.G., Chang, H.E., Freedman, E.G., Foxe, J.J.ÂĄ, Hong-Wang, K. Sex-specific and age-related progression of auditory neurophysiological deficits in the Cln3 mouse model of Batten disease. Journal of Neurodevelopmental Disorders, 2025, 17: 67.
8. Rao S, Azuero-Dajud R, Lorman V, Landeo-Gutierrez J, …… Foxe, J.J.; RECOVER EHR and; RECOVER Pediatric Cohorts. Ethnic and racial differences in children and young people with respiratory and neurological post-acute sequelae of SARS-CoV-2: an electronic health record-based cohort study from the RECOVER Initiative. EClinicalMedicine. 2025, 80: 103042.
Albert Einstein College of Medicine
Center for Visual Science at the University of Rochester
University of Rochester
Johnny Foxe
