11/13/2025
The removal of the black box warning on hormone replacement therapy (HRT) for women marks a significant shift in medical guidance.
Previously, the warning indicated potential risks, such as an increased risk of blood clots and certain cancers, which led to concerns and hesitancy around HRT use.
Recent research has led to a reevaluation of these risks, showing that, when prescribed correctly and used in appropriate age groups and health conditions, HRT can offer significant benefits, particularly for managing menopause symptoms and preventing bone loss.
The removal of the warning reflects medicine's greater understanding of HRT's safety and effectiveness, offering women greater access to treatments that can improve quality of life.