11/10/2025
Seeking Health is such a great organization. Like Minds has an upcoming announcement about our affiliation with them... also, I always encourage others to check out their supplements and products and of course their President's book (Dr. Ben Lynch) "Dirty Genes". Such a great read for understanding genetics (especially how to understand the issues surrounding Methylation) Get the book on Amazon: https://a.co/d/eWZpcuM
Ready to go deeper into your genetic mood map?
Meet MAOA👋
COMT’s lesser-known, but also powerful, cousin.
Both genes 🧼 clear key neurotransmitters like dopamine, norepinephrine, and serotonin, heavily shaping your mood, focus, and stress response.
But while COMT works mostly in the prefrontal cortex (think focus, motivation, and estrogen metabolism)...
MAOA is your emotional regulator — managing the brain’s 👊 fight-or-flight 🏃chemistry.
🧠 MAOA’s job?
Break down neurotransmitters ❗after they’ve done their job.
That moment of calm after stress? That’s MAOA at work.😲
⚖️ MAOA vs. COMT: Similar Roles, Different Circuits
MAOA and COMT symptoms often mirror each other—but key differences matter:
🔹 MAOA plays a larger role in serotonin breakdown
🔹 It’s X-linked, meaning it works differently in men and women
🔹 MAOA symptoms often begin in childhood or adolescence (aggression, impulsivity, mood swings)
🔹 MAOA = externalizing symptoms: anger, antisocial behavior
🔹 COMT = internalizing symptoms: anxiety, overwhelm, mood instability
📌 Your Takeaway:
If you’re navigating mood challenges
❗ don’t stop at COMT. Look at MAOA.
MAOA sets the baseline tone for emotional regulation.
COMT adjusts your dynamic range for stress, cognition, and hormone balance through life.
And yes 🫢—these genes can interact.
When both are “dirty,” the risk for emotional dysregulation goes up—especially in sensitive or clinical populations.
💬 Comment “MAOA” to dive deeper into how to optimize fast or slow MAOA activity—and which supplements best support your unique brain chemistry.
Would you rather learn about COMT?
Comment: "COMT" 👀