RTHM

03/16/2026

03/13/2026

03/11/2026

The Patient-Led Research Collaborative and the RTHM Clinic are excited to release the Long COVID Treatment Guide. The Treatment Guide is a resource meant to help patients and clinicians navigate the treatment options that could be tried for people with Long COVID.

Since there are no FDA-approved treatments for Long COVID, all pharmaceutical options are for off-label indications backed by clinical studies, as well as patient and clinician expertise. One of our intentions was to gather this evidence all in one place, so that patients and clinicians can make decisions informed by evidence. We also wanted to present that information in a format that would allow for the review of one treatment in a brief clinician visit. The Treatment Guide is not an exhaustive list, nor is it intended to serve as medical advice — it is an educational resource for patients and clinicians to use together.

To support the use of a listed treatment, we used both data from early clinical studies in Long COVID and data from infection-associated chronic conditions (IACCs) that are common in this patient population, such as postural-orthostatic tachycardia syndrome (POTS) and mast cell activation. Our decision to include a treatment was guided by existing evidence from the literature and the patient community, clinician expertise, as well as the Harvard/Stanford TREATME study organized by Dr. Martha Eckey, which surveyed patient-reported treatment effectiveness among 3,900 people with Long COVID or myalgic encephalomyelitis. We also prioritized listing treatments that were backed by clinical treatment guides for Long COVID and commonly comorbid IACCs.

Thus, the Treatment Guide is an evidence-supported resource hub that can help inform clinicians and patients about treatment options that could be tried today. We hope this resource can help patients evaluate the options available to them and can inform clinicians on the supporting evidence for off-label treatment options for Long COVID.

Download the guide here: https://www.rthm.com/treatmentguide

03/10/2026

Complex illness does not move in straight lines. It behaves more like a system of interlocking gears that respond to constant internal and external factors.

In this clip, Dr. Jennifer Curtin and Dr. Zac Spiritos explain why treating conditions like EDS, ME/CFS, and Long COVID requires thinking beyond isolated symptoms. A treatment that helps one area can affect another. This is exactly where new AI tools may show promise in mapping interwoven patterns and starting to predict what is more likely to help, and what might cause unintended side effects.

Watch the full conversation to hear how real world clinical experience and emerging technology are offering new ways to untangle this complexity and support more personalized next steps in care.

📽️: https://youtu.be/-eMC4Wxel3I

03/05/2026

Are you struggling with PEM?

Post-exertional malaise, or PEM, is not just feeling extra tired. It is a dramatic worsening of multiple symptoms (often called a “crash”) that can be triggered by going beyond your body’s energy threshold via physical, mental, and/or emotional exertion. Even sensory overload (like too much light or sound exposure) can trigger PEM in some cases. Even fun activities like hanging out with friends or cheering for your favorite sports team can trigger PEM. A PEM crash can leave someone bedbound or functioning at a significantly lower baseline for days, weeks, or even months or more. Having PEM makes it difficult to plan activities, work, go to school, engage in social activities, or manage everyday tasks.

PEM is a hallmark symptom of ME/CFS, and occurs in many people with Long COVID as well. For people who experience PEM, it is often the symptom that most severely limits daily life and independence.

Research-supported treatments exist that may help reduce the frequency and/or severity of PEM crashes and raise one’s energy threshold before PEM is triggered. We know it can take some time to find a treatment that works, and we’ve seen many patients positively respond, sometimes drastically, to these medications.
Have any of these treatments made a difference for your PEM symptoms? Share in the comments, please.

For treatment suggestions personalized to your health history, try RTHM’s HIPAA-compliant intelligence platform.

www.rthm.com

02/27/2026

RTHM just made supplements a whole lot easier.

You can now order high-quality supplements directly through RTHM, shipped straight from the manufacturer, at 25% off to start.

No more guessing, we've curated a list of the top brands you can trust.
For patients navigating complex conditions, supplements often mean trial and error. We’re working to make that process smarter, more data-driven, and easier to manage, all in one place.

If you’ve been meaning to streamline what you’re taking (or rethink it entirely), check out RTHM’s HIPAA-compliant intelligence platform for supplement and treatment suggestions personalized to your health history.

www.rthm.com

02/25/2026

Complex illness treatment isn't about FDA-approved silver bullets. It's about sifting through countless options to find what works uniquely for each person.

In her discussion with Dr. Zac Spiritos, Dr. Jennifer Curtin shares the frustration of clinical practice, always wondering, "Did I miss the one treatment that could get someone from bedbound to back in school?" Treatments that help one patient can backfire for another with similar symptoms, hinting at hidden patterns too complex for humans alone to spot.

That's why she and her team built RTHM, the HIPAA-compliant AI platform she wished existed when she got sick, so patients would no longer face endless trial and error.

Watch the full conversation to hear how real-world experience is turning frustration into personalized breakthroughs.

📽️: https://youtu.be/-eMC4Wxel3I

02/20/2026

Today is . Did you know more than 63 million adults in the U.S.—that’s 1 in 4 —are family caregivers for a chronically ill, disabled, or aging loved one? What does this mean for YOUR life?

Have you wondered how you can help a caregiver in your life - specific, actionable ways you can help?

If you’re a family caregiver, have you ever had a well-meaning friend or relative say, “I know you’re overloaded — let me know how I can help,” and your mind just goes blank?

Or maybe no one asks, but you wish people knew how they could lighten your load?

Here’s something that can help:

👉 Supporting Family Caregivers: 25 Heartwarming Ways You Can Make a Difference: https://bit.ly/49jIql4

This practical, heartfelt list offers specific ways to:
🌿 Stay in touch (nearly 1 in 4 caregivers report feeling alone)
🛒 Help with errands and daily tasks
💌 Show care and connection in meaningful, doable ways

Let’s build a community of care for those who quietly hold families together with love, patience, and grit. 💙

If this resonates, please share this post so more people know how they can support the caregivers in their lives.

Whether you’re a caregiver yourself or someone who loves one — thank you for being part of this circle of compassion.

02/19/2026

A recent study found that people who develop neurological Long COVID show changes in their blood that are similar to biomarkers seen in Alzheimer’s disease and other forms of neurodegeneration. Researchers followed essential workers who had blood samples collected both before the pandemic and again after COVID infection, giving them a rare chance to measure what actually changed over time.

After infection, people with ongoing symptoms like brain fog, dizziness, headaches, and loss of smell or taste showed large increases in a protein called pTau-181, which is linked to brain cell stress. On average, levels rose by nearly 60%, and increases were even higher in people whose symptoms lasted longer than 1.5 years.

This study wasn’t designed to answer whether Long COVID causes Alzheimer’s or dementia, but it does show that persistent neurological symptoms in Long COVID are connected to measurable biological changes, not just stress or deconditioning. The study findings suggest some people may have an underlying vulnerability that infection can worsen and highlight the need for prevention, early monitoring, and better treatments for Long COVID.

👉 Read the full study: https://doi.org/10.1016/j.ebiom.2025.106106

Authors: Xiaohua Yang, Ashley Fontana, Sean A.P. Clouston, Benjamin J. Luft

02/17/2026

In a recent The POTScast episode, RTHM co-founder and Chief Medical Officer Dr. Jennifer Curtin joined host Jill Brook to talk about RTHM’s new HIPAA-compliant AI platform that is specifically tailored to complex chronic illness patients.

Learn about the critical role of high-quality, vetted research that is underpinning RTHM’s platform. It currently integrates over 2,000 curated papers and continues to grow.

🎙️Listen now—link in bio!
https://ow.ly/5xhr50YhihJ

Help keep conversations like this going: https://ow.ly/9rWX50YhihQ