Gladstone Institutes

01/12/2026

Last year, we honored Rudolf Jaenisch, the 2025 recipient of the Ogawa-Yamanaka Stem Cell Prize.

Watch the award ceremony and his scientific lecture.

On December 1, 2025, Gladstone Institutes honored Rudolf Jaenisch, MD, the 2025 recipient of the Ogawa-Yamanaka Stem Cell Prize. A pioneer in epigenetics an...

01/11/2026

An HIV diagnosis upended San Diego resident Jim Dunn’s life. But his willingness to participate in an end-of-life program is helping scientists to better understand the disease and hopefully find a cure.

‘The Last Gift: Jim’s Courage, Our Hope’ shares the story of late San Diego resident Jim Dunn and his role in research aiming to find a cure for HIV

01/09/2026

Alex Marson and his collaborators at Stanford University developed a genomic mapping technique that helps close the gap in understanding why certain genetic variants are tied to disease.

These maps could clarify confusing biology and pinpoint disease-causing genes that are ripe for intervention.

01/08/2026

From fellowship support to global conference experiences, mentorship transforms careers. As we mark , we celebrate the mentors whose belief and support ripple through generations of scientists. 🧬💛👩‍🔬

Robert and Linda Mahley’s commitment to trainee development continues through Gladstone’s annual Career Advancement Awards.

01/06/2026

Gene editing technologies developed in recent years offer the promise of repairing genetic mutations that cause disease. But putting these therapies to use typically requires creating a separate treatment tailored to each disease-causing mutation—an approach that becomes impractical given that a single gene can harbor dozens or even hundreds of different mutations.

Now, scientists at Gladstone Institutes and UCSF have developed a new strategy that removes the mutated copy of a gene—or critical portions of it—from cells while leaving the healthy copy intact. The approach could be 20 to 40 times more efficient than personalizing individual therapies for each mutation, with just a few variations of the therapy treating nearly all patients with an inherited disorder.

Read more about this study on our website. Link in comments.

01/05/2026

Check out this episode of the Stem Cell Podcast with Deepak Srivastava.

Srivastava talks about his lab's recent work investigating heart defects in Down syndrome and strategies for delivering therapies to the heart. He also talks about how to incentivize the development and commercialization of cell and gene therapies.

Dr. Deepak Srivastava is the President of the Gladstone Institutes and Director of the Roddenberry Stem Cell Center. His lab is focused on the gene networks that guide cardiac development. He talks about their recent work investigating heart defects in Down syndrome and strategies for delivering the...

01/02/2026

Today’s biomedical researchers are relentlessly searching for genes that drive disease, with the goal of creating therapies that target those genes to restore health.

When a single gene is the culprit, the approach can be rather straightforward. But for the majority of diseases, in which multiple genes—sometimes thousands of them—are implicated, the task of pinpointing the connections becomes far more difficult.

But a new genomic mapping technique may change that. In a study published in Nature, researchers from Gladstone Institutes and Stanford University leveraged a comprehensive method of probing every gene in a cell to connect diseases and other traits with their underlying genetic machinery. These maps could clarify confusing biology and pinpoint disease-causing genes that are ripe for intervention.

Read more about this study on our website 👉 https://bit.ly/44VTwt9

01/01/2026

Cheers to a new year and new discoveries 🥂

This past year was filled with scientific progress, meaningful connections, and moments that reminded us why research matters. Thank you to everyone who followed along, supported our work, and championed science with us.

Swipe through for a few highlights from the year. We can’t wait to see what the next chapter brings as we continue working toward breakthroughs that improve lives.

01/01/2026

Have you seen our latest Science in Seconds video?

Seth Shipman and his team recently identified seven new retrons from environmental bacteria by sampling soil and water in nature

Seth Shipman and his team recently identified seven new retrons from environmental bacteria by sampling soil and water in nature.

12/30/2025

Bringing complex science into clear view. Check out this animated explainer that shows how scientists reprogram cells to study disease and design new therapies.

It’s one of our favorite videos of the year because it highlights not just what we do, but how science works.

In this animated short, Deepak Srivastava explains how scientists can reprogram ordinary skin or blood cells back in time—turning them into induced pluripotent stem cells which are capable of becoming any cell type in the body.

12/29/2025

A team of scientists at Gladstone developed a new gene editing method and showed that only a few variations of the therapy could treat the majority of patients with Charcot-Marie-Tooth disease.

Read more about this study on our website ➡️ https://bit.ly/4j2uFtB

12/29/2025

A new documentary, featuring Gladstone scientists, follows Jim Dunn’s end-of-life decision to donate his tissues to HIV research.

A new documentary follows Jim Dunn’s end-of-life decision to donate his tissues to HIV research.