Gladstone Institutes

04/11/2026

For the millions of people who carry the gene APOE4, the strongest known genetic risk factor for Alzheimer’s disease, their brain activity may begin changing long before any memory problems appear.

Now, researchers at Gladstone Institutes have uncovered a precise chain of molecular events behind those early changes and identified a potential way to reverse them.

Read more about this study on our website. Link in comments.

04/10/2026

Science is moving at lightning speed.

AI is transforming how scientists decode the human genome—helping pinpoint which tiny changes in DNA actually drive disease. What once took years of trial and error can now be predicted in days, guiding researchers toward the most impactful experiments.

As Katie Pollard shares, these models are learning the “rules” of DNA—accelerating discovery and bringing us closer to understanding, preventing, and treating disease in entirely new ways.

Read more at the link in comments.

04/10/2026

👏 👏 Congratulations to Gladstone investigator Ryan Corces, who has been named a 2026 winner of the Pershing Square Foundation’s MIND Prize.

This award recognizes next-frontier thinkers who are uncovering a deeper understanding of the brain and cognition.

The prize, issued annually to eight scientists, seeks to catalyze high-impact neuroscience research.

04/09/2026

Gladstone's Melanie Ott and Nadia Roan are central to a groundbreaking effort to create the world’s first map of how HIV affects the immune system at a single-cell level.

Funded by amfAR, the AI-driven project will establish a crucial scientific resource to speed the development of better treatments, and possibly a cure, for HIV.

A groundbreaking effort aimed at transforming scientific understanding of how the virus disrupts immune function and persists in the body throughout treatment.

04/08/2026

Every part of your body is aging every day. Over decades, the cells in your heart, brain, and lungs gradually change in ways that can boost your risk of heart disease, dementia, and other age-related conditions.

Scientists have long tried to map those changes, but most studies examine cells one snapshot at a time, missing the bigger picture of how aging actively unfolds.

Now, researchers at Gladstone, working with NVIDIA, have built an artificial intelligence (AI) model that tracks the molecular details of exactly how cells throughout the body change over time.

Ultimately, that could let them identify drugs or other interventions to slow or reverse the cellular changes driving age-related diseases, including heart disease and dementia.

Visit our website to read more about this study. Link in comments.

04/08/2026

Scientists have found a way to create cancer killing CAR-T cells inside the body.

UCSF Scientists have found a way to create cancer killing CAR-T cells inside the body. This eliminates the costly, time-consuming manufacturing process that ...

04/07/2026

DNA sequencing is faster and more affordable than ever—but there’s a major problem: we still don’t fully understand what most genetic changes actually mean.

Deepak Srivastava explains how scientists are tackling one of the biggest challenges in medicine—interpreting the human genome. By combining cutting-edge lab technologies with the power of artificial intelligence, researchers are beginning to uncover patterns in our DNA that could reveal disease risk long before symptoms appear.

04/07/2026

Gladstone will be adding space for up to 30 new labs!

Gladstone Institutes’ 105,000-square-foot lease is one of the largest such deals in the city so far this year.

04/06/2026

It’s Graduate Student Appreciation Week—a moment to recognize the people behind so much of our momentum.

Our graduate students push ideas forward, navigate challenges with creativity, and ask the questions that lead to what’s next. Just as importantly, they bring a spirit of collaboration that makes Gladstone thrive.

Let’s show our appreciation—drop a thank you to a grad student 👇

04/06/2026

For most colorectal cancer patients, immunotherapy still falls short.

Karin Pelka is on a mission to change that—using AI to decode tumors and reveal the hidden signals that could make treatments work for more people.

Discover how AI-driven research is uncovering how tumors evade immunity, paving the way for new colorectal cancer immunotherapies that could benefit more patients.

04/05/2026

What if the next generation of vaccines could do more?

In the Hoffmann Lab, Kim Dam is rethinking how vaccines are built—combining the best of traditional approaches with newer technologies like mRNA to create stronger, smarter immune responses.

Why does it matter? Because some of the world’s toughest diseases—like HIV, malaria, and influenza—still don’t have highly effective vaccines.

By building better platforms, we can open the door to protecting against what once felt out of reach.

04/05/2026

What if AI didn’t just give answers—but helped scientists ask better questions?

At Gladstone, researchers like Seth Shipman are pushing AI and molecular tools to uncover what we don’t yet understand about disease—and turn uncertainty into insight.