Gladstone Institutes

12/12/2025

Among his myriad accomplishments, Rudolf Jaenisch—winner of the 2025 Ogawa-Yamanaka Stem Cell Prize—was the first to demonstrate the potential of induced pluripotent stem cells to treat disease.

12/12/2025

A study led by Ken Nakamura reveals how mitochondrial failure can set off the chain of events that leads to Parkinson’s disease.

A new study shows how failing mitochondria and rising oxidative stress may set off key steps in Parkinson’s disease.

12/11/2025

Scientists at Gladstone Institutes are developing new technologies for genome editing, which can correct mutations that cause disease. To build these technologies, they use parts from bacteria, including bacterial immune systems called retrons.

Seth Shipman and his team recently identified seven new retrons from environmental bacteria by sampling soil and water in nature.

In this video, the researchers explain how they co-opt the retrons’ ability to produce DNA inside cells and combine it with the CRISPR system to create better tools for genome editing, which can one day be used as therapeutics for a range of diseases.

12/11/2025

Gladstone researcher Alex Marson and his collaborators at Stanford University developed a genomic mapping technique that helps close the gap in understanding why certain genetic variants are tied to disease.

Findings of the new study in Nature could streamline scientific discovery and accelerate drug development.

12/10/2025

Today we celebrate Nobel Prize Day by honoring Jennifer Doudna and Shinya Yamanaka—two Gladstone scientists whose groundbreaking discoveries in CRISPR gene editing and iPS cell technology continue to drive innovation and transform the future of medicine.

12/09/2025

Certain brain cells are responsible for coordinating smooth, controlled movements of the body. But when those cells are constantly overactivated for weeks on end, they degenerate and ultimately die. This new observation made by scientists at Gladstone may help explain what goes awry in the brains of people with Parkinson’s disease.

Link in comments to read more about this study.

12/08/2025

🧬 Breakthrough in CRISPR research! Our scientists have uncovered fascinating differences in gene editing between dividing and non-dividing cells. This could be a game-changer for developing therapies for neurological disorders.

The CRISPR gene editing technique has had a dramatic influence on biomedical research, and has even been applied to a few humans to treat disease. Since it | Cell And Molecular Biology

12/08/2025

Gladstone Wrapped is here!

This year, our scientists published more than 170 publications in scientific journals, Gladstone was mentioned in the news over 600 times, plus we had a special visit, and a major milestone for our president.

12/07/2025

In this audio clip, Gladstone President Deepak Srivastava explains groundbreaking research in cardiac regenerative medicine. Scientists have discovered how to reprogram adult cells using specific master genes, potentially offering new treatments for heart failure.

12/06/2025

The gene editing tool known as CRISPR-Cas9 is changing what’s possible for treating a wide range of diseases caused by genetic mutations. But so far, attempts to use the technology to address brain-based genetic disorders have proved challenging in the lab.

Scientists have now discovered why. In a study published in Nature Communications, researchers from Gladstone, the Innovative Genomics Institute, and UC Berkeley have shown that neurons and other nondividing cells respond differently to CRISPR-Cas9 gene editing than dividing cells.

Link in comments to read the full story.

12/05/2025

Congratulations to our six Gladstone scientists recognized as 2025 Highly Cited Researchers by Clarivate!

Their groundbreaking work places them among the world’s most influential researchers, highlighting a decade of excellence and impact in their fields. 🌟👏

The featured scientists include global leaders in gene editing, data science, and immunology.

12/05/2025

Today is J. David Gladstone's birthday—the man behind our name.

His generosity paved the way for our journey.