02/21/2026
This case says yes.
A patient treated for C. difficile developed a progressive ANC drop after switching to oral vancomycin solution:
Other causes excluded
Colonoscopy showed inflamed mucosa → ↑ systemic absorption
ANC recovered after switching to fidaxomicin
Takeaway: Oral ≠ risk-free, especially with inflamed gut mucosa.
Clinicians: Would you routinely monitor CBCs in patients on oral vancomycin?
Yes / No...why?
Read more here: https://hubs.la/Q0438j-X0