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Mike Robinson, Researcher OG
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Let’s talk real-life results with a powerful 2023 case study: “Cannabidiol in the Management of Comorbid Rheumatoid Arth...
03/07/2026

Let’s talk real-life results with a powerful 2023 case study: “Cannabidiol in the Management of Comorbid Rheumatoid Arthritis, Lupus, and Raynaud’s Disease” (American Journal of Endocannabinoid Medicine). A 50-year-old woman dealing with chronic pain, swelling, and limited mobility from multiple autoimmune conditions tried high-dose CBD isolate (600mg/day) after years of failed relief from conventional meds like prednisone and tramadol.

Within 72 hours, her pain began to ease. By day 10, her mobility and mood had improved. By day 28, her pain score had been cut in half, inflammatory markers (CRP and ESR) had dropped, and her quality-of-life metrics had improved across all nine domains. No THC, no drug interactions, and no return to her previous meds.

So what made the difference? ECS Balance. Autoimmune diseases like RA and lupus are rooted in immune system chaos. CBD doesn't just reduce pain—it helps regulate the Endocannabinoid System, calming immune overactivation, reducing inflammation, and restoring cellular communication. This case demonstrates how CBD supports the ECS in a way that shifts the body toward balance, rather than just alleviating pain.

We need more trials, no doubt. However, this is a clear signal: when you provide the ECS with the right kind of help, such as high-quality CBD, it can reset systems that medications alone cannot reach.

-Mike Robinson, The Researcher OG

Before I drop this one, understand ALS is one of the harshest neurodegenerative conditions out there – and modern medici...
03/07/2026

Before I drop this one, understand ALS is one of the harshest neurodegenerative conditions out there – and modern medicine still has no real answers. That’s why this brand new review from February 12, 2025 caught my eye: “Amyotrophic Lateral Sclerosis, the Endocannabinoid System, and Exogenous Cannabinoids: Current State and Clinical Implications.”

Researchers looked at why cannabinoids like CBD, THC, and CBG keep showing up as potential tools against ALS. In lab models, these cannabinoids reduced inflammation and oxidative stress, protected neurons, and even delayed disease onset and progression in ALS mice. In the few human studies we have, patients reported less muscle rigidity, fewer cramps, better sleep, reduced pain, and improved mood – basically all the things that destroy quality of life with ALS.

Here’s the bigger picture: ALS involves multiple systems failing at once – nervous, immune, metabolic. The Endocannabinoid System (ECS) sits at the crossroads of all of it. When the ECS is out of balance, neurodegeneration accelerates. When you feed it the right cannabinoids, you’re not just masking symptoms – you’re giving the body tools to regulate inflammation, protect neurons, and slow the chaos.

That’s ECS Balance in action. It’s not a cure, but it's a way to help the body fight back on its own terms. And that applies way beyond ALS – because when you support your ECS, everything from sleep to pain to immune function starts trending back toward balance.

-Mike Robinson, The Researcher OG

With Raphael Mechoulam, I always felt honored to be in his presence and humbled. A return email, every single one, was a...
03/06/2026

With Raphael Mechoulam, I always felt honored to be in his presence and humbled. A return email, every single one, was a gift from a man far too busy for someone like me. Although I was aware that many awards are not given after a person has passed away, I sent over 25 requests to former Nobel Laureates, hoping that perhaps there was a way. However, the bottom line is that Nobel Prizes are only granted to living individuals.

He will go down in history, no doubt, in one way as a great example of why we need to seek nominations of those deserving of such a highly esteemed award. At the same time, they are alive. It was disheartening to receive only a few responses, as I felt like 'if only I had done this much earlier, it would have been this easy to get a response, so I'll never do that again.'

We all take things, people, so much for granted. In his 90s, one thing we will always know, regardless of whether or not he was a Nobel Laureate, is that Professor Raphael Mechoulam was a great man who holds the highest medals of honor within all of our hearts.

He made time for those who wanted his help, or a bit of guidance. Mechoulam was such a fabulous person for the people.

~Mike Robinson, The Researcher OG

We've faced challenges; it took me 5 years of perseverance to build a soil-to-oil farm that creates the brands to help y...
03/06/2026

We've faced challenges; it took me 5 years of perseverance to build a soil-to-oil farm that creates the brands to help you with your own challenges. The world has issues with its Endocannabinoid System, and as much as we'd love to say that using any Cannabis at all would help the ECS, that isn't true.

Our bodies rely on an equilibrium that maintains homeostasis, which occurs when we have the right endocannabinoids, endocannabinoid-like fatty amides, and receptors for neurotransmitters, allowing the countless receptor systems within us to function correctly.

It's about our lifestyle; the choices we make in what we put in our bodies will determine our overall happiness, health, and mental clarity. So many of us started out smoking w**d, then it got called Cannabis as the legalization movement swept across the US. We learned about all these very cool cannabinoids, and even terpenes - how they work and what they'll do.

But, we were not taught about the ECS and how unique everyone's physiology is. What balances one person by downregulation (use of THC) could actually upregulate another person. What upregulates someone, such as CBGa, could cause calm in another and induce bliss by stimulating the drastic circulation of endocannabinoids.

It's easy to see that we all have to learn how extracts or the plant works on us uniquely, instead of following any leader. One thing I do know for sure is that most people are very imbalanced, dysfunctional ECS situations cause us to gain issues we don't want, and all those problems of the past can also creep back up on us.
ECS Balance, it's the middle of the road that most have never been on in Cannabis.

-Mike Robinson, The Researcher OG

"Role of the Endocannabinoid System in Fibromyalgia" Published Feb 26, 2025 - Abstract: Fibromyalgia is a chronic diseas...
03/06/2026

"Role of the Endocannabinoid System in Fibromyalgia" Published Feb 26, 2025 - Abstract: Fibromyalgia is a chronic disease marked by extensive musculoskeletal pain, persistent fatigue, and cognitive impairments. Despite its high prevalence, the underlying pathological mechanisms of fibromyalgia are still not fully elucidated.

Emerging research has identified the endocannabinoid system as an essential factor in modulating pain and other symptoms related to fibromyalgia. The endocannabinoid system plays a key role in many physiological processes such as pain perception, mood regulation, and inflammation. This review provides a powerful analysis of the principal aspects of fibromyalgia and examines the evidence regarding the involvement of the endocannabinoid system in this condition, focusing on its influence on pain modulation.

Moreover, the dysregulation of the endocannabinoid system in fibromyalgia patients will be examined, with an assessment of how variations in endocannabinoid levels and receptor activity may contribute to the clinical manifestations of the condition. A better knowledge of this physiological system could lead to the development of novel strategies for managing fibromyalgia.
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ECS Dysfunctions, as I refer to them as, are often due to an individual consuming too much of a good thing - THC. But, they can be hereditary and also occur with illness and disease. The importance of getting balanced, and staying that way is imperative. Treat your ECS with extreme care, it's the master regulator of your body.

-Mike Robinson, The Researcher OG

"THC, CBD and minor cannabinoid CBDV differently modulate hippocampalneurons firing" April 9, 2025 ABSTRACT: Cannabis sa...
03/06/2026

"THC, CBD and minor cannabinoid CBDV differently modulate hippocampal
neurons firing" April 9, 2025 ABSTRACT: Cannabis sativa L. presents a very complex composition that includes several secondary metabolites besides the two main compounds, Δ9 -tetrahydrocannabinol (THC) and cannabidiol (CBD). Many of these minor cannabinoids are still under investigation and are arousing increasing interest for their biological effects and potential therapeutic roles.

Cannabis sativa extracts, either properly purified and enriched with cannabinoids, were tested here on the neuronal activity, by monitoring the spontaneous firing rate and the bursts generation of cultured hippocampal neurons. In particular, we focused on the combined effect of THC, CBD and cannabidivarin (CBDV), a non-psychoactive homologue of CBD whose side chain has two fewer carbon atoms, and their related standard compounds.

We found that standard THC, recognised for its psychoactive impact and side effects including anxiety and paranoia, significantly decreased the spontaneous firing discharge of cultured hippocampal neurons, whether applied alone or in combination with standard CBD at comparable concentrations. In contrast, the firing
activity did not exhibit any significant alterations when CBD was administered alone.

When C. sativa extracts were tested, we found that CBDV was able to reverse the inhibition of the firing discharge caused by the mixture of THC and CBD. Furthermore, when administered alone, CBDV significantly increased the firing discharge of
hippocampal neurons. In all tested conditions, the effects exerted by standard compounds or extracts were restored to control conditions after 24 hours from administration. Overall, these data unravel a novel action of CBDV in reverting the detrimental effect exerted by the THC+CBD on neuronal firing activity.
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This research study had some merit, but also didn't make much sense to do. The easiest way for people not to have a 'detrimental effect' from THC + CBD would be to not use one of the two cannabinoids causing it. I love CBDV, but found this study to minimize it a bit.

Mike Robinson, The Researcher OG

There are several reasons why I've always preferred CBGa/CBG for Autism. In a study conducted in 2018, researchers from ...
03/05/2026

There are several reasons why I've always preferred CBGa/CBG for Autism. In a study conducted in 2018, researchers from Stanford University studied how compound anandamide levels in children with ASD compared to controls. They found that the concentration was significantly lower, a key finding as anandamide resembles THC in structure and functions similarly in the endocannabinoid system.

The study supports the theory that THC may hold therapeutic potential when used to treat autism symptoms but goes even further in proving that Clinical Endocannabinoid Deficiency Syndrome is playing the role and the acidic mother major, CBGa, is known to help balance issues out when Anandamide is lacking.

Another study in 2013 showed that endocannabinoid receptors in autistic children were found to be more active than those of healthy subjects, suggesting an imbalance within the endocannabinoid system.

Again, this points us toward the mother major cannabinoid CBGa, known for balancing the endocannabinoid system.

Research has supported that the same path to allowing a THC user to find efficacy again is the route to treating sensory processing issues that come with Autism.

-Mike Robinson, The Researcher OG

Kids should not be prescribed drugs like Morphine, Oxy, and Fentanyl for pain when they can easily use Cannabinoid Medic...
03/05/2026

Kids should not be prescribed drugs like Morphine, Oxy, and Fentanyl for pain when they can easily use Cannabinoid Medicine. There's no reason to create addicts of the future out of young patients that need relief just because our government has stalled the end of prohibition.

We've got children who have beat cancers while their parents fought off authorities and others fighting seizures that kill, all while having to break a law that never should have existed.

It's up to the same medical community to speak up about this wrong, make it right, and push for all to learn about the Endocannabinoid system so that when doctors encounter patients using the plant, they can hopefully be as knowledgeable as someone in a Facebook group.

It seems like a burden on the people, the system, and the plant to move it to Schedule 3 instead of simply ending the prohibition on the plant itself and examining which cannabinoids should be scheduled, which would likely be semi-synthetics as they're favored by Pharma.

-Mike Robinson, The Researcher OG

Patients undergoing Maintenance Therapies for Opioid Use Disorder should NOT be tested for Cannabis by doctors who are p...
03/04/2026

Patients undergoing Maintenance Therapies for Opioid Use Disorder should NOT be tested for Cannabis by doctors who are part of the problem and helped create the pandemic of addiction that's spread across the globe. Cannabis helps significantly; it depresses the CNS, allowing the medications used for Maintenance Therapies (Suboxone, Methadone) to work far better with less use.

Opioid Use Disorder is treated by Cannabis all on its own; it's how I gained my freedom from 24 years of addiction. But, for those in some Maintenance programs, the plant or its extracts are not allowed as it will compete with the pharma drugs and enable a patient to use less. The potential for addiction isn't there, so all other excuses are Western Medicine lies that we've grown used to.

Most know that these alternatives to hardcore addiction are now being used on patients who got in over their heads with pharmaceuticals of just about any type. I have clients on small doses of 25 mg of Methadone for Benzo addiction who can not use cannabinoids.

As it is, I believe Maintenance Therapies to be a pharmaceutical scam in which drugs are sold at huge profits to treat patients in clinics. It's not different from the earnings of the pain clinic; it's, for the most part, the next move by the failing healthcare industry to try to look good when, in reality, it's replacing the income of pain and other patients with addicts they created now in treatment.

The bottom line is that addiction is out of control, and we need to make a recovery from the epidemic. Fentanyl has flooded our streets, and the old-school drugs many knew of in the 80s are now just white powder with varying ratios of that in it.

To change what's going on, we must Free the W**d, and this doesn't mean putting it under a schedule created for pills; it means altogether off of schedules as it should never have been on one.

Cannabis Prohibition must end and the plant removed from Schedule I so treatment centers no longer consider it a dangerous drug and allow people who need it to have it.

-Mike Robinson, The Researcher OG

Everything we do requires balance, from the foods we eat to how we spend our time. Finding the right balance is often a ...
03/04/2026

Everything we do requires balance, from the foods we eat to how we spend our time. Finding the right balance is often a matter of trial and error, but it's worth the effort, especially when using cannabis.

When our endocannabinoid system is balanced, we're more likely to feel happy and fulfilled and succeed in whatever endeavor we're undertaking.

When treating our life's issues with cannabis, being in balance is essential. For THC to work at its optimum level in my body, it loves other cannabinoids in their complete spectrum concentrates, also working to balance it.

In everything I do...

When I feel I'm veering off course, I step back and ask myself what I must do to bring myself back into balance. It's the first step to success in any area of your life.

It could be exercise or yet another change in my diet - but most of the time, it has something to do with the cannabinoid intake I have.

-Mike Robinson, The Researcher OG

Early cannabis exposure and the adolescent brain have been studied heavily, and new imaging research keeps refining the ...
03/04/2026

Early cannabis exposure and the adolescent brain have been studied heavily, and new imaging research keeps refining the conversation. The narrative, for decades, was simple: change the reward system and you create a gateway. The science is more precise than that.
A longitudinal imaging study titled “Associations Between Ma*****na Use and Neural Response to Reward in Young Adults,” 2016, examined how cannabis exposure related to nucleus accumbens activation during reward anticipation. Researchers found that greater ma*****na use over time was associated with reduced activation in reward circuitry when anticipating monetary rewards.
That sounds dramatic until you understand what it actually means.
Reduced activation is not the same as addiction escalation. It reflects altered reward processing. The nucleus accumbens is part of the dopaminergic system that evaluates salience and reinforcement. Changes in its activation pattern suggest recalibration, not inevitability.
Here is where the politics and headlines often overshoot the biology.
If early cannabis exposure automatically drove progression to harder drugs, we would see overwhelming epidemiological evidence of escalation. We do not. The majority of cannabis consumers do not transition to co***ne, he**in, or methamphetamine. Shared liability theory continues to show that environmental stress, trauma, and genetic vulnerability better predict polysubstance use than cannabis exposure alone.
The ECS, our Master Regulator, plays a central role in shaping dopamine tone during adolescence, a period of intense synaptic pruning and circuit refinement. Introducing cannabinoids during that window can influence the setting of reward thresholds. That influence can show up in imaging data.
But altered reward signaling does not equal drug-seeking destiny.
Biology adapts. Context determines outcome. Neurodevelopment is dynamic. The data show modulation of reward circuitry, not a programmed march toward other drugs.
That is the difference between science and fear-based storytelling.
-Mike Robinson, The Researcher OG

Using THC, CBD, and CBG can be excellent, especially when a patient is dealing with pain, nausea, appetite loss, sleep d...
03/04/2026

Using THC, CBD, and CBG can be excellent, especially when a patient is dealing with pain, nausea, appetite loss, sleep disruption, and the mental grind that comes with oncology care. But surviving cancer is rarely about one compound, one pathway, or one symptom. It is about regulation.

The ECS, our Master Regulator, is one of the body’s core control systems for immune tone, inflammatory signaling, stress response, and cellular survival messaging. When those systems are dysregulated, tumors can exploit the chaos. When regulation improves, the body tends to fight smarter.

Here is the part most consumers miss.

THC can relieve pain and nausea while also interacting with signaling pathways involved in apoptosis and cellular stress in preclinical models, including ceramide-related mechanisms that are relevant to glioma research. CBD can support anxiety, sleep, and inflammatory tone, and cannabinoids as a class have a meaningful clinical history in chemotherapy-induced nausea and vomiting when used carefully alongside standard care. CBG is also showing preclinical relevance, including colon cancer models in which it inhibited carcinogenesis and tumor growth, with TRPM8-linked effects reported in the literature.

But none of that is the whole story.

Cancer survival is about the terrain. Immune surveillance. Chronic inflammation. Metabolic stress. Mitochondrial dysfunction. Sleep fragmentation. Appetite collapse. Cortisol-driven dysregulation. The ECS spans those intersections, including immune behavior within the tumor microenvironment, which researchers are actively mapping right now.

So yes, THC, CBD, and CBG can be strong allies, alone or combined. The deeper win is when a patient leans into ECS support as a daily strategy, not a last-minute rescue. That means protecting sleep, stabilizing blood sugar, lowering inflammatory load, supporting mood, and using cannabinoids with intention rather than chasing relief in panic.

-Mike Robinson, The Researcher OG

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