Santa Barbara Nutrients

02/23/2026

02/19/2026

Interim Clinical Trial Results Show Significant Efficacy of KetoCitra® in Combination With Nutritional Changes in Autosomal-Dominant Polycystic Kidney Disease

Interim results from a controlled clinical trial presented at ASN offer evidence for metabolic therapy in ADPKD.
The study, led by Juntendo University in Tokyo, tracked the efficacy of KetoCitra® as part of the Ren-Nu™ ketogenic nutrition program.

Key Findings at 3 Months:
-Clinically Meaningful Kidney Volume Decline: Subjects in the intervention group experienced a statistically significant 5.01% reduction in Total Kidney Volume (TKV). During the same period, the control group’s kidneys grew by 8.03%
-Renal Function Stability: The intervention group showed a stabilization of eGFR (+0.59 ml/min/1.73 m²), while the control group continued to show a decline (-1.57 ml/min/1.73 m²).
-High Tolerability and Adherence: The study reported a 100% adherence rate, with zero participants discontinuing.

The Mechanism:
Targeting the metabolic vulnerability of cystic cells (glucose dependency) via nutritional ketosis, supported by the exogenous ketone BHB and alkaline citrate to normalize urinary pH.

Conclusion:
A non-pharmacological approach that is clinically safe, effective and feasible for patients.

FOR IMMEDIATE RELEASE SANTA BARBARA, CA – Santa Barbara Nutrients (SBN) is pleased to announce the first interim results from an ongoing clinical trial to study the safety and efficacy of SBN’s medical food KetoCitra® in combination with education on ketogenic nutrition and lifestyle changes in...

02/12/2026

Delighted to announce that two members of the SBN team will be presenting scientific talks at the Keto Live Conference in Switzerland in June:
Melina Messing is SBN's Director of Research of the Ren-Nu Program
Guido K.W. Frank is a member of SBN's advisory board
-> Program here: https://www.european-keto-live-centre.com/

02/07/2026

Santa Barbara Nutrients Announces Publication of Peer-Reviewed Study Reporting Real-World Outcomes of KetoCitra and the Ren-Nu Program for Polycystic Kidney Disease. Key findings from the study:

> 103 participants with ADPKD
> Improved kidney function
> High adherence to nutritional ketosis
> Improvement of obesity/overweight
> Reduction in anti-hypertensive medication use
> Reductions in pain
> Safety markers remained stable

Read the full news release here:

FOR IMMEDIATE RELEASE Santa Barbara Nutrients Announces Publication of Peer-Reviewed Study Reporting Real-World Outcomes of Ren-Nu™ Program for Polycystic Kidney Disease Santa Barbara, CA — January 21, 2026 — Santa Barbara Nutrients, Inc., a science-driven biotechnology and nutrition company f...

02/05/2026

Santa Barbara Nutrients Welcomes Renowned Psychiatrist-Scientist Dr. Guido K.W. Frank to Advisory Board

Santa Barbara Nutrients (SBN), a science-driven company dedicated to advancing metabolic health solutions, recently announced the appointment of Dr. Guido K.W. Frank, MD to its Advisory Board. Dr. Frank will play a central role in advising SBN’s research strategy, especially in exploring metabolic therapies for mental health disorders.

Dr. Frank is a Professor of Psychiatry at UC San Diego. His research and clinical work spans more than three decades. He is a board-certified adult, child, and adolescent psychiatrist, and he provides clinical care through the UC San Diego Health system, including the Child & Teen Psychiatry Program and the Eating Disorders Center for Treatment and Research, where he serves as Director of Psychiatry at the Medical Behavioral Unit at Rady Children’s Hospital San Diego.

Read full news release here:

FOR IMMEDIATE RELEASE Santa Barbara Nutrients Welcomes Renowned Psychiatrist-Scientist Dr. Guido K.W. Frank to Advisory Board SANTA BARBARA, Calif. — January 27, 2026 — Santa Barbara Nutrients (SBN), a science-driven company dedicated to advancing metabolic health solutions, today announced the ...

02/04/2026

Thank you for your testimonial, Christian. We are glad to hear about your success!

01/15/2026

New video about the work of the PKD Free Alliance.

Melina Messing, Scientific Director of Ren-Nu at Santa Barbara Nutrients, talks to Kevin Schnurr and Melinna Sanchez from the PKD Free Alliance about their program to support in vitro fertilization services for individuals with polycystic kidney disease.

Melina Messing, Scientific Director of Ren-Nu at Santa Barbara Nutrients, talks to Kevin Schnurr and Melinna Sanchez from the PKD-Free Alliance about their p...

01/11/2026

📢 Santa Barbara Nutrients is looking for people who would like to help in our marketing efforts! The only requirements are that you have a deep interest in polycystic kidney disease, and have a basic understanding of marketing and social media (you do not need to be an expert). This role will provide the unique opportunity to work with a team of PKD scientists, nephrologists, dietitians, and people affected by PKD (we already have 11 on the team!). So if you are interested or have questions please email us at talent@sbnutrients.com.

12/18/2025

Thank you to SBN Practitioner Network Member, frequent SBN Blog Post writer and Medical Director of Integrative Kidney Solutions, .isreb for reviewing these highly encouraging interim results from the first ketogenic diet study on Japanese ADPKD patients utilizing KetoCitra®. We appreciate all that you do for SBN and Renal Health! Don’t miss his latest SBN Guest Blog Post at link below:
🔗https://santabarbaranutrients.com/blogs/kidney-health/three-month-interim-analysis-of-ketogenic-metabolic-therapy-in-japanese-adpkd-patients

12/18/2025

Thank you to SBN Practitioner Network Member, frequent SBN Blog Post writer and Medical Director of Integrative Kidney Solutions, Dr. Majd Isreb for reviewing these highly encouraging interim results from the first ketogenic diet study on Japanese ADPKD patients utilizing KetoCitra®. We appreciate all that you do for SBN and Renal Health! Don't miss his latest SBN Guest Blog Post on this below:

This interim analysis published in the Journal of the American Society Of Nephrology (JASN) and presented at the latest ASN Kidney Week, reports early results from the first clinical study in Asia testing ketogenic metabolic therapy, using a ketogenic diet supported by beta-hydroxybutyrate and alkal...

11/09/2025

Santa Barbara Nutrients team at Kidney Week in Houston.
Planning the next revolution in nephrology