03/23/2026
Why choose a methylated B vitamin?
Deficiency†
Deficiency in any of the B vitamins can create a breakdown of
metabolic processes that protect health. Many medications
deplete certain B-vitamins including acetaminophen, aspirin,
ibuprofen, oral contraceptives and SSRIs, along with stress and
poor diet. Deficiencies of folic acid, B6 and B12 can specifically
impair proper methylation, which affects many aspects of health.
Folate†
Folate is a water soluble member of the B complex vitamins that
is critical for maintaining optimal methylation. Folate is found
naturally in foods such as fruits and dark leafy vegetables, but
can be easily destroyed by cooking or processing. Additionally,
enzyme defects, malabsorption and congenital deficiency of
5-methylenetetrahydrofolate reductase (5-MTHFR), an enzyme
required for the conversion of folic acid to its bioactive form
5-methyltetrahydrofolate (5-MTHF), can result in an impaired
ability to activate folic acid. In individuals with a genetic defect
of this enzyme, supplementation with 5-MTHF has been shown
to be beneficial.1 5-MTHF is required as a methyl group donor
for the production of mood regulating neurotransmitters
such as serotonin, the synthesis of melatonin, as well as
DNA production and repair.1 5-MTHF also donates its methyl
group to vitamin B12 (cobalamin), forming methylcobalamin.
Methylcobalamin helps convert the amino acid metabolite
† These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
homocysteine into the amino acid methionine. Consistent
recycling of homocysteine is vital to supporting cardiovascular and arterial health.
*Source: Ortho Molecular
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