How Percepta® works.
Your brain is the most complex organ in the universe. It weighs only three pounds, or about 2% of your body’s weight. Yet it uses 20-30% of the calories you consume, 20% of the oxygen you breathe, and 25% of the blood flow in your body; it consist of 85% water. There are approximately 100 billion nerve cells (i.e. neurons) in your brain, and up to a quadrillion synapses1. Starting in your early adulthood, there is a slow but deliberate accumulation of two neurotoxic proteins in your brain as you age.
Your brain is the most complex organ in the universe.
Beta-amyloid plaques form between nerve cells (i.e. neurons) and have been shown to kill surrounding nerve cells.
First is the brain accumulation of an insoluble (aggregated) specific protein known as the “beta-amyloid protein” (i.e. “Aβ” or “Abeta”). Beta-amyloid protein deposits in the form of “plaques” (that look like “meatballs” in the brain under a light microscope) have been shown to be instrumental in killing healthy neurons (i.e. nerve cells). The accumulation of “plaques” in the brain leads to a decline in hippocampus-dependent memory and cognition in the normal aging brain. Dr. Snow’s laboratories developed and patented methods to produce “plaques” in a test-tube: (identical to what is seen in the human brain) and used these methods to screen for and identify natural “plaque-reducing” nutraceutical ingredients.
The second neurotoxic protein that accumulates in the aging brain is known as the “tau protein” and forms twisted paired helical filaments inside neurons (or nerve cells) called “tangles”. Tangles accumulate inside neurons and cause neurons to die. “Tangles” look like dried spaghetti strands under a light microscope.
Dr. Snow’s research team was the sole supplier of the tau 4-repeat domain to Sigma Aldrich which was sold to researchers all over the world to make “tangles” in a test-tube or petri dish9. Thus, in the normal aging brain, you have the accumulation of both “plaques and tangles” that cause neurons to die; connections between nerve cells (called synapses) to disintegrate; and memory and cognition to progressively decline.
Neurofibrillary tangles consisting of tau protein form inside neurons and also cause neurons to die.
Compounds or agents able to disaggregate and reduce the accumulation of “plaques and tangles” have been shown to lead to memory improvement and a reduction in memory decline. The only difference between a healthy brain and an aging brain is the number of “plaques and tangles” in the brain. The more “plaques and tangles” you accumulate as you normally age, the worse your memory, focus, concentration and cognition will be.
Percepta® is postulated to be the world’s first oral nootropic to target the real reason we lose memory as we age: The accumulation of brain “plaques and tangles.”
PERCEPTA ® MEMORY SUPPORT
The Discovery of Percepta®
PTI-00703® cat’s claw from the Amazon rainforest. MemorTea f®rom the mountains of China. The one-two punch of distinct plant extracts, and postulated inhibitors and reducers of brain “plaques and tangles” comprise Percepta™, the first nootropic to target the real reason we lose memory as we age.*
Cat’s claw (Uncaria tomentosa) is a woody vine found in the Amazon rain forest. PTI-00703® is our proprietary source of cat’s claw bark powder identified for “plaque & tangle” reducing activity.*
Cat’s claw is an ancient plant extract used for centuries by Peruvian tribes for immune support
In the early 2000’s, while a Research Associate Professor of Pathology at University of Washington, Dr. Alan Snow and his world-class research teams went on a screening expedition after they developed a proprietary assay to identify the most potent inhibitors/reducers of brain “plaques”. They screened many dietary supplements that were available in the marketplace for human consumption at the time, looking for a natural inhibitor and reducer of brain “plaques” (that accumulate in the normal aging brain).
Brain “plaques”, and then later “tangles”, were the two main culprits identified to be the actual cause of normal memory loss as one gets older. The Snow neuroscience team, while at the University of Washington, identified an ancient plant extract known as Uncaria tomentosa (cat’s claw) that was used for centuries by the Peruvian tribes for immune support and enhancement1-2.The cat’s claw ingredient was found to be a potent inhibitor and disrupter of brain “plaques” (that consisted of a protein called “beta-amyloid protein”)3-5. The Snow research teams spent years screening different sources to identify the specific, proprietary cat’s claw that produces the most potent activity against brain “plaques”: PTI-00703® cat’s claw.
Dr. Snow and his research teams have now identified the specific and newly discovered polyphenol ingredients within PTI-00703® cat’s claw that are responsible for the potent activity that they first identified. These ingredients and the exact mechanism of action of how this amazing plant extract works to reduce brain plaque load and improve memory will soon be published for the world to see7.
MemorTea is® our proprietary source of Oolong tea (Camellia sinensis) identified for “plaque & tangle” reducing activity.*
Years later, the Snow research teams also developed appropriate models to recapitulate brain “tangles” (consisting of a protein called “tau protein”) in a test-tube, the other part of the spectrum of memory loss in normal individuals. Since at the time, various peer-reviewed publications were touting the potential use of green tea and their specific polyphenol components as inhibitors and disrupters of “plaques and tangles”.
The one-two punch of distinct plant extracts, and postulated inhibitors and reducers of brain “plaques and tangles,” make up Percepta®
The Snow research team then screened different kinds of teas including green tea (not oxidized or fermented), oolong tea (partially oxidized or fermented), and black tea (totally oxidized or fermented), from various sources to also identify the most robust inhibitor/ disrupter of both brain “plaques and tangles”. They then identified a specific and proprietary “oolong tea” (known as “MemorTea®”) from a secret source, found to reduce and inhibit “plaques and tangles” as well.
This one-two punch of two distinct plant extracts and postulated inhibitors and reducers of brain “plaques and tangles” make up the innovative synergistic components of Percepta®. Percepta® is the world’s first natural plant-derived nootropic to target brain “plaques and tangles” for memory support and enhancement.*
Dr. Alan Snow has joined forces with Dr. Rudolph Tanzi (one of the world’s most foremost authorities on brain aging) to form Cognitive Clarity Inc. for the development of “Breakthrough Nutraceuticals for the Aging Brain.”
Percepta® has thus been specifically formulated and developed by two of the world’s most renowned authorities on brain aging.
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, diagnose, cure or prevent any disease.
