Seyyes TMS

04/27/2023

Study* findings show that energy metabolism is disturbed in individuals with MDD. The interplay of the gut microbiome and blood metabolome most likely plays a significant role in energy and lipid metabolism, as these changes in lipid metabolism are consistent with the gut dysbiosis and processes that are disrupted in and associated with individuals diagnosed with MDD.
* The cohort study used data from participants in the UK Biobank cohort (n = 500 000; aged 37 to 73 years whose blood was profiled for metabolomics and from the summary statistics from a 2019 genome-wide association study of depression were used for the mendelian randomization (individuals with MDD = 59 851; control individuals = 113 154).

An international team of medical researchers has found a link between major depressive disorder (MDD) and an interplay between the gut microbiome and the blood metabolome. For their study, reported in the journal JAMA Psychiatry, the group analyzed data in the UK Biobank.

04/09/2023

Blood flow to the entire brain is supply-limited (not demand-based), tightly regulated, and remains mostly consistent throughout the day. Research suggests that as a part of the brain experiences an increase in activity, it is only allowed slightly more blood flow, but at the expense of diverting blood flow from other brain regions.

Neuroscientists have typically thought of energy supply to the brain as demand-based. A supply-limited view offers another perspective toward aging and why multitasking can be difficult.

01/26/2023

A new sensitive and simple electrochemical sensor test for abnormal blood levels of dopamine detection in biological fluids could pave the way for the molecular diagnosis and earlier disorder/disease detection of neurological illnesses levels. The new procedure utilizes carbon quantum dots and an ionic liquid formulated with several mineral anions and organic cations for early detection of potential neurological disorders and diseases.

Altered levels of the neurotransmitter dopamine are apparent in various conditions, such as Parkinson's disease and depression.

01/25/2023

Blood RNA transcripts reveal that multiple neurodegenerative diseases harbor similar (and differential) dysfunctional cellular alterations in their fundamental biological cell processes, including transcription regulation, degranulation, immune response, protein synthesis, apoptosis, cytoskeletal components, ubiquitylation/proteasome, and mitochondrial complexes that are also affected in the brain and reveal common themes across many neurodegenerative diseases. Identifying each regional vulnerability will reveal the unique disease mechanisms and ultimately lead to noninvasive treatments for neurological disorders and diseases.

Multiple neurodegenerative disorders harbor similar fundamental dysfunctional cellular processes.

01/23/2023

Following spinal cord injury, a course of daily noninvasive suprathreshold high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) activates the BRAF canonical downstream effectors MAP2K1/2 and modulates the expression of a set of regeneration-related transcription factors and enables functional CST axon regrowth and sprouting.

High-frequency repetitive transcranial magnetic stimulation (rTMS) activates MAP2K signaling and enhanced axon regeneration and functional recovery following spinal cord injury.

01/16/2023

Physical exercise induces a cycle of fatigue and recovery that is paralleled by the cycle of the fragmentation and repair of the mitochondria (the specialized organelles inside every cell that is responsible for energy production) networks. The disruption of the cycle of repairing dysfunctional mitochondria and restoring their connectivity is linked to chronic, age-related diseases. Physical fitness induces a cycle of fatigue and recovery (that is paralleled by a cycle of the mitochondrial network rebuilding) that manages the aftermath of metabolic demand and restores both performance and mitochondrial function. This not only extends lifespan but also enhances health and quality of life.

Exercise is a nonpharmacological intervention that improves health during aging and a valuable tool in the diagnostics of aging-related diseases. I...

01/15/2023

Not only does belief in misinformation lead to poor evaluations, decisions, and actions by people but the "continued influence effect" alters future reasoning, even after incorrect beliefs have been corrected. As leaders, educators, scientists, etc., we all need to make certain that only facts and truth are communicated in clear and understandable manners.

Misinformation is influential despite unprecedented access to high-quality, factual information. In this Review, Ecker et al. describe the cognitive, social and affective factors that drive sustained belief in misinformation, synthesize the evidence for interventions to reduce its effects and offer....

01/12/2023

New research is attempting to better understand (beyond neuronal energy metabolism) how mitochondrial dysfunction contributes to neurological disorders and diseases and has yielded emerging information about the mitochondrial basis of neural health in neurodegeneration, organelle dynamics, cell death, immunometabolism, etc. Distinct mechanisms and pathways that protect mitochondrial health also intersect to produce neurological health support, metabolic plasticity, and stress responses in the nervous system (as well as to contribute to the pathology of neurological disorders and diseases) and are integrated within these mitochondrial signaling pathways.

01/05/2023

Just an interesting fact to share... "If you were to rescale a hydrogen atom so that its nucleus was the size of a basketball, the nearest electron would sit around two miles away."

Early scientists didn’t know it, but we do now: The void in the universe is alive.

01/04/2023

What do organic yogurts, sauerkraut, kefir, sourdough bread, and kimchi (please read the nutrition labels to confirm the content) possibly have to do with neurodegeneration and aging? They each contain the naturally occurring probiotic bacterium, lacticaseibacillus rhamnosus HA-114, which reduces neurodegeneration and has neuroprotective effects. When this gut bug is added to the diet, it suppresses the progression of motor and other neuronal degeneration, which leads to neurological (and, ultimately, physiological) disorders and diseases.

Lacticaseibacillus rhamnosus HA-114, a non-commercial probiotic reduces neurodegeneration and has neuroprotective effects in lab models of ALS.

12/31/2022

Very well stated... "I think we need to spend more time talking about health and vitality and capabilities (instead of talking about disease and disability and death). And so we can change the tone of the conversation to prevention, instead of reaction." -- The University of Miami, Miller School of Medicine, Dr. James Galvin, director of the Comprehensive Center for Brain Health

Why do some people develop Alzheimer's disease and others don't? What makes one person's brain healthier than another's? And what can be done to improve, or at least slow, a brain's deterioration?

12/30/2022

Novel biomarkers (brain-derived tau) similar to biomarkers found in CSF are used to detect AD’s neurodegeneration in simple blood sample tests, avoiding lengthy and complicated scheduling and accessibility matters of expensive neuroimaging. Both MRI and CSF sampling present serious economical and practical limitations but this convenient and reliable method using biomarkers in blood samples is minimally invasive and requires fewer resources. This procedure meets the AT(N) Framework guidelines set by the National Institute on Aging and the Alzheimer’s Association.

A blood-based biomarker that tracks neurodegeneration in Alzheimer’s disease and differentiates it from other dementias is lacking. Gonzalez et al. report the d