Optispan Podcast

Optispan Podcast Optispan is a vision for what healthcare should be.

Join us on a journey of discovery as we explore the science of longevity and optimal healthspan ("Optispan").

02/20/2026

The wellness industry wants you to buy grounding mats and green powders. Here's what actually works.
We ranked 12 wellness interventions based on evidence, not marketing.

Most wellness hacks are noise. Focus on the fundamentals with actual evidence behind them.
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02/19/2026

We put 8 popular longevity interventions in a bracket. Matt picked the winners.

This is a teaser for something coming in March. Stay tuned!

What would your picks be? Drop them below.
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You can't feel chronic inflammation, but it's aging you faster.As we age, the immune system becomes dysregulated, leadin...
02/18/2026

You can't feel chronic inflammation, but it's aging you faster.

As we age, the immune system becomes dysregulated, leading to a persistent, low-grade inflammatory state called "inflammaging." Even without infection or injury, your body stays in a pro-inflammatory mode.

The good news? It's measurable and it's manageable.

Inflammation isn't just a symptom of aging, it's a driver. Swipe to understand what's happening and what you can do about it
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02/17/2026

NAD+ boosters are everywhere in longevity circles. But does the science support the hype?

NAD (nicotinamide adenine dinucleotide) is an essential molecule required for energy production and thousands of cellular processes. It's not optional, your cells literally can't function without it.

NAD boosters are promising, but we're not ready to recommend them for the general population. If you have specific mitochondrial dysfunction or are working with a physician monitoring biomarkers, there may be a case. For most people? The fundamentals (sleep, exercise, nutrition) will move the needle more.
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02/13/2026

Not all airport snacks are created equal.
When you're traveling, food choices matter, especially for metabolic health and satiety.

It is easy to forget when you are in a busy environment like an airport, but it is important to try to prioritize whole foods with protein, healthy fats, and fiber. Minimize ultra-processed foods with added sugars and seed oils.
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02/12/2026

We're in the golden era of health wearables, but which one should you actually use?
Nick breaks down 5 wearables he's tested over the last 10 years, from a clinical perspective. Here's what actually works (and what doesn't).

Nick's take: There's no one "best" wearable. It depends on what you're optimizing for: sleep, performance, convenience, or peace of mind.
What's your go-to wearable? Drop it in the comments!
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02/11/2026

"You don't need to spend hours in the gym every day to get phenomenal results."

Shannon Anderson is 63, works out 3 hours per week, and just built the strongest body of her life.
Not 3 hours per day. 3 hours per week.

Monday, Wednesday, Friday
50 minutes per session
Resistance training focused

That's it.
And the results? She's gained 3 lbs of muscle, dropped body fat, and feels better than she did in her 40s.
On the latest Optispan Podcast episode, Matt sits down with Shannon Anderson to talk about:

Her 46-year journey from eating disorders to true health
Why hormone therapy (testosterone, estrogen, progesterone) changed everything for her at 60
How she transformed her body with just 3 workouts per week
The difference between vanity-driven health and health from the inside out
What she's training for at 63 (spoiler: adventures with her daughters when they retire in 30 years)

The truth: You don't need to live in the gym. You just need consistency, the right protocol, and a data-driven approach.
Listen now, link in bio.
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Muscle mass is one of the strongest predictors of longevity, yet most people lose 30-40% of their muscle by age 70.Here'...
02/10/2026

Muscle mass is one of the strongest predictors of longevity, yet most people lose 30-40% of their muscle by age 70.
Here's why that matters and what you can do about it.
After 30, you lose 3-8% of your muscle mass every decade. This isn't just about aesthetics—it's about survival.

Why muscle matters:
Metabolic health - Muscle regulates glucose and insulin sensitivity. Less muscle = impaired glucose control and higher diabetes risk.
Bone density - Muscle provides the mechanical loading that keeps bones strong. Lose muscle = weaker bones, more falls, higher fracture risk.
Cardiovascular health - Low muscle mass is an independent risk factor for cardiovascular disease. Studies show up to 2x higher risk of major cardiac events.
Cognitive function - Muscle secretes myokines that reduce inflammation and support brain health.
Independence - Muscle strength predicts functional capacity. Lose too much muscle = loss of independence and up to 6 years shorter lifespan.

The good news? This is preventable, and in many cases, reversible.

The research is clear:
Muscle-strengthening activity reduces all-cause mortality by 15-20%
Combined with aerobic exercise, risk drops by up to 40%
Gait speed (a proxy for muscle strength) predicts longevity, fastest quartile has 50% lower all-cause mortality than slowest

Start now. Your 80-year-old self will thank you.
Swipe through for the complete breakdown of why muscle = longevity →
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02/09/2026

If you caught the Super Bowl yesterday, you probably saw commercials for GLP-1 agonists. Here's what you need to know about oral vs. injectable formulations.
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02/06/2026

After 30, you lose 3-8% of your muscle mass every decade.

Here's why that matters and how to stop it. Muscle loss isn't just about aesthetics. You don't need to lift heavy weights. Lighter weights work just as well when you push close to fatigue. This is your insurance policy against disability, fractures, and metabolic disease.

Start now. Your 80-year-old self will thank you.
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02/05/2026

Can't do a pull-up yet? Here's how to get your first one. Pull-ups are one of the most functional upper body movements you can do.

Consistency beats perfection. Train 3x/week, track your progress, and celebrate the small wins. That first pull-up is coming.

Why pull-ups are so important: Grip strength is a longevity predictor. Upper body pulling strength prevents postural decline as you age. And pull-ups are functional for daily life: picking things up, pulling yourself up if you fall.

Where are you starting? Drop your pull-up goal for 2026 below
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Some longevity influencers spend $10,000+/month on peptides, incremental hacks, and 100+ supplement stacks.Most of it is...
02/05/2026

Some longevity influencers spend $10,000+/month on peptides, incremental hacks, and 100+ supplement stacks.

Most of it is hype. Weak evidence. Low ROI.

The truth: most longevity benefits come from interventions that cost very little.

The hierarchy:
Master the $0 interventions first
Add precision diagnostics and a few targeted interventions

Longevity isn't about money. It's about consistency, data, and evidence.

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