RSP Amino Acids, LLC

10/27/2025

Celebrating my 14th year on Facebook. Thank you for your continuing support. I could never have made it without you. 🙏🤗🎉

04/08/2025

RSP AMINO ACIDS, LLC
CLOSE-OUT, RESIDUAL
MATERIAL: 136 chiral core amino acids, 3.5+Kg
TOTAL VALUE AT LIST $,1,982,985.00
CLOSE-OUT PRICE: $198,298.00
To order, request pro-forma invoice with instructions and spreadsheet from cava_mark@hotmail.com

Send a message to learn more

08/02/2024

D-amino acids
Better access kidney flow,
Current one’s no good,…

I think diagnostics are behind the 8-ball on diagnosis or poorly guided by insurance gates.

🙏🏽❤️⛑❤️🙏🏽

d-Amino acids are the recently detected enantiomers of l-amino acids. Accumulating evidence points their potential in solving the long-standing critical problems associated with the management of both chronic and acute kidney diseases. This includes estimating kidney function, early diagnosis and pr...

06/05/2024

Long peptide synthesis
Finding the next protein drugs,
New system work,…

Having provided a bulk of chiral amino acid analogues to medicinal and protein chemistry
from RSP, we’re always interested in new technology to deploy synthetic amino acids, often with built-in pharmacophores, and drug like properties.

MIT chemists have developed a protocol to rapidly produce protein chains up to 164 amino acids long. The flow-based technology could speed up drug development and allow scientists to design novel protein variants incorporating amino acids that don’t occur naturally in cells.

02/19/2024

HGH ups growth
Of everything, glycogen up,
Stops glucose uptake,…

Whoa! Powerful stuff, not an advocate for medical use. It’s secreted by the pituitary gland and increases growth of all cell types. Advanced growth uses glucose across disease types meaning diabetes weaves its way through all aspects of human metabolism. I’m an old student who loves science and medicine. ❤️🙏🏽⚕️🙏🏽❤️

Human growth hormone (HGH), also known as somatotropin, is a 191 amino acid single-chain polypeptide produced by somatotropic cells within the anterior pituitary gland. As its name implies, scientists originally found it to be responsible for growth regulation during childhood. However, research has...

09/11/2023

WHEP domain function?
Amino acid tRNA
Synthetase review,...

These authors discovery hypothesis that these synthetases may be valuable drug targets in chronic disease.

Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme that catalyzes the ligation of tryptophan (Trp) to its cognate tRNA[trp] during translation via aminoacylation. Interestingly, WRS also plays physiopathological roles in diseases including sepsis, ...

05/26/2023

Covalent bond forms
PAXLOVID antiviral
Cysteine protease,...

It is termed a covalent inhibitor of this viral cysteine protease which the virus uses to get in. The molecule is a beautiful example of a peptido mimetic looking like Val-Pro-Gln, constrained glutamine glutamic acid. Presumably the viral enzyme-SH attacks the nitrile.

It is a great example using some fancy amino acid analogues, nice work at Pfizer.

Nirmatrelvir is an antiviral medication developed by Pfizer which acts as an orally active 3C-like protease inhibitor.[3][4][5][6][7] It is part of a nirmatrelvir/ritonavir combination used to treat COVID-19 and sold under the brand name Paxlovid.[8]

05/05/2023

Protein effectors
Could block, activate function
In solid tumors,…

From a medicinal chemistry standpoint, non-catalytic inhibitors didn’t make sense, i.e., were outside the box 📦 of protein function or better effected outside the rate of main function, for transport or other metabolic turnover. However, careful thought like 👍 this could find something to pe*****te specific tumor cells, a problem in all cancers. More importantly, small molecule effectors with chiral bias adds specificity to the medicine profile, the power of chiral drugs. Better?they could inhibit or promote protein-protein interaction, cooperative association which increases function. Cool 😎, he’s screening new chiral buffers to change protein function. The challenge here will be proving effective dose, why protein effectors don’t make it (takes too much medicine). In cancer it could be a different story with chiral bias toward protein function. 🙏🏽Cravatt🙏🏽

By comparing how mirror image versions of small molecules impact clusters of proteins, Scripps Research scientists can identify potential new drug targets.

03/13/2023

Interesting article by someone who lived through the first successful introduction of a hypertension drug. BMS also was a leader in biologicals, antibodies and were among the first to pair small molecule chemistry with immunology for more directed drug action against disease. It is still a great reference articles 6 April 2007 , By Dr Edward W. Petrillo , Spring 2007

6 April 2007 , By Dr Edward W. Petrillo , Spring 2007
Lean Thinking for Drug Discovery – Better Productivity for Pharma

Lean Thinking for Drug Discovery – Better Productivity for Pharma By Dr Edward W. Petrillo Success in drug discovery controls the success of the pharmaceutical enterprise. The molecular structure of every drug candidate, and the body of knowledge that will guide its use in the treatment of disease...

03/06/2023

What’s nature’s scaffold?
Alpha amino acids
Use to fight disease 🦠

Gif search string “ribosome.”

02/23/2023

Richard B. Silverman, Basic Science to Blockbuster Drug

The story of Lyrica, a gamma amino acid drug

Richard B. Silverman, Northwestern University - Basic Science to Blockbuster Drug: Invention of Lyrica

12/30/2022

Keys for drug transport,
Available, nontoxic
Secret of Pharma

There were a few tricks to drug innovation, one was replacing Hydrogen with Fluorine as in the cortisone family. Many more prodrugs incorporate amino acids as bioavailable, nontoxic building blocks. Peptides analogue with amino acid caps like Gilead's sofosbuvir and lots more including Merck's Enalapril ending in normal proline.

Amino Acids in the Development of Prodrugs

Although drugs currently used for the various types of diseases (e.g., antiparasitic, antiviral, antibacterial, etc.) are effective, they present several undesirable pharmacological and pharmaceutical properties. Most of the drugs have low bioavailability, ...