11/26/2025
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If you have MTHFR (or high homocysteine), here’s something most people never hear about…
TMG.
It’s a simple nutrient … but it supports a backup methylation pathway that your body can use even when MTHFR isn’t doing its job.
Why this matters:
🧬 When methylation slows down →
homocysteine builds up →
inflammation, low energy, mood issues, cardiovascular strain.
TMG helps convert homocysteine back into methionine … kind of like unclogging the methylation “drain.”
But here’s the nuance:
• Not everyone with MTHFR has high homocysteine
• If you do, TMG can be incredibly helpful
• Typical dosage: 600–1,800 mg/day, depending on labs
• And if you’re sensitive, start low and see how you feel
⚠️ Pro tip:
Some people do better taking TMG away from methylfolate or medication.
TMG also works best alongside folate, B12, B6, and magnesium … all the core methylation nutrients.
I hope you found this helpful! 💚 Wanna learn more? 🤓
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