11/11/2025
When people talk about fertility, the focus is usually on women … but research actually shows MTHFR may impact male fertility even more.
Why?
Because MTHFR mutations can raise homocysteine, throw off folate and B12 metabolism, and affect sperm quality and DNA integrity.
If you know you have MTHFR (or suspect it), here’s what to check:
✔️ Homocysteine levels
✔️ RBC folate
✔️ Methylmalonic acid (B12 status)
If things look off balance, you may benefit from supporting your methylation pathways with:
🔹 Methylfolate (active B9)
🔹 Methylcobalamin (active B12)
🔹 P5P (active B6)
These nutrients help “prime the methylation pump” … and can take a few weeks to a few months to bring things back into balance.
Healthy methylation = healthier sperm + better fertility potential. 🧬