03/31/2026
Ever feel like your emotions are more intense than they should be… or harder to come down from?
It's often believed that your genes determine your destiny. That's not necessarily true, but they do influence how your body processes things like stress, mood, and neurotransmitters.
And one gene that plays a big role in this is MAO-A.
MAO-A is an enzyme that breaks down your neurotransmitters - primarily serotonin.
Mutations here will slow the break down. When it's slower (+/+) serotonin and stress-related neurotransmitters hang around longer than they should.
This can look like:
• Feeling emotions very deeply
• Irritability or mood swings
• Anxiety or feeling on edge
• Overthinking or rumination
• Trouble “letting things go”
• Feeling overwhelmed more easily
A build up of serotonin also can interact with histamine systems contributing to histamine-related issues.
This looks like:
• Headaches
• Flushing
• Skin Reactions including Itching
• Sinus Congestion
• Racing Heart
• Food Reactions
Most people treat these as separate issues:
“I have anxiety”
“I have histamine intolerance”
But in some people, they’re connected through slower breakdown pathways.
Most people assume:
👉 “Low serotonin = I need more”
But if MAO-A is slower, adding more serotonin support can sometimes make you feel even worse:
• Increase irritability
• Increase emotional intensity
• Make you feel overstimulated
If you're experiencing any of these symptoms, it's worth knowing your MAO-A status. Better yet, pair it with an Organic Acid Test and you can see much more easily what's happening with your serotonin. 🌿
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