03/11/2026
DAO (Diamine Oxidase) is an enzyme made in the gut that helps break down histamine from food.
Although histamine get's a bad reputation, it isn’t bad. Your body actually needs it for immune function and digestion.
The problem happens when histamine builds up faster than your body can clear it.
This can happen if:
◾ Your genetics reduce DAO activity
◾ Your gut lining is inflamed or damaged
◾ You have too many histamine producing gut bacteria
◾ Certain medications block DAO
◾ Your histamine “bucket” is already full
When DAO isn’t working efficiently, histamine can build up and trigger symptoms like:
🚩 Headaches or migraines
🚩 Flushing or skin reactions
🚩 Hives or itching
🚩 Anxiety or a racing heart
🚩 Sinus congestion
🚩 Digestive upset
🚩 Feeling worse after fermented foods, wine, aged cheese, or leftovers
Because DAO is produced in the gut lining, supporting gut healing is often a key piece of improving histamine tolerance.✨