Baack Lab

Baack Lab Michelle Baack’s research is focused on establishing the underrecognized role of lipid disturbances in the developmental origins of health and disease .

Congratulations Kyle Siemers MD, PhD student in the Baack Lab who was selected to present her work at the 13th World Con...
09/10/2025

Congratulations Kyle Siemers MD, PhD student in the Baack Lab who was selected to present her work at the 13th World Congress of DOHaD in Buenos Aires, Argentina. Yesterday, she presented a fabulous talk entitled “Combined high lipid and glucose exposure impairs trophoblast mitochondria- mediated fatty acid uptake” which demonstrates mechanisms involved in deficiency of beneficial long chain, unsaturated fatty acids in infants born to diabetic and obese mothers. Congratulations Kyle! So proud of you.

Welcome Alex Johnson, our newest lab member who is now up and running to lead the InvitroWOMB precision DOHaD work and t...
09/09/2025

Welcome Alex Johnson, our newest lab member who is now up and running to lead the InvitroWOMB precision DOHaD work and the translational studies under Sanford’s PLaCENTA Outcomes study. Alex is an AMAZING addition!!!

09/09/2025

🔬✨ Microscopy Monday ✨🔬

This glowing 3D image shows two rat embryos at just 4.5 days of development — with blue marking the cell nuclei and green highlighting the mitochondria. A glimpse of life at one of its earliest stages!

📸 Image credit: Abigail Klein

Congratulations to Abby Klein and the Baack Lab on their recent publication in Biomedicines entitled “The Transgeneratio...
08/24/2025

Congratulations to Abby Klein and the Baack Lab on their recent publication in Biomedicines entitled “The Transgenerational Impact of High-fat Diet and Diabetic Pregnancy on Embryonic Transcriptomics and Mitochobdrial Health”. The paper shows lasting consequences for preimplantation embryos for three generations! Next, we hope to reveal interventions that stop the vicious generational cycle of obesity and cardiometabolic disease. Congratulations authors: Abigail Klein, Benjamin Derenge, Malini Mukherjee, Srikrishna Reddy, Tricia Larsen, Prathapan Ayyappan. Ty Gandy, Kyle Siemers, Mike Kareta and Michelle Baack.

What an amazing US DOHaD society conference in Portland this year!!! Thank you to the OHSU staff and leadership team. C...
08/06/2025

What an amazing US DOHaD society conference in Portland this year!!! Thank you to the OHSU staff and leadership team. Congratulations to Kyle Siemers who was not only a nationally elected leader helping organize the 2025 meeting, but also an award winner with a perfect poster score. Way to go Kyle!!!! The Baack lab is so proud of you!!!

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2301 East 60th Street N
Sioux Falls, SD
57104

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