Prairie Education and Research Cooperative (PERC) was founded to facilitate cardiovascular and vascular clinical research. PERC was conceptualized to integrate state of the art medical research and bedside patient care. From its conception, PERC has provided intelligent direction, skillful execution, proven results and diverse research activities. To facilitate these research endeavors, PERC has been instrumental in fostering new cooperative efforts between physicians, medical industry, and the clinical research community. In this regard, PERC’s personnel have promoted the clinical introduction of new pharmaceuticals, cardiovascular techniques and medical devices. Over the past two decades, the evolution of this cooperative effort has been reflected in the growth of PERC to its present size. PERC is an excellent resource for project, site and data management.