WashU Medicine Knight ADRC

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The Washington University Knight ADRC is one of around 30 centers funded or otherwise supported by the National Institute on Aging with the collective aim of facilitating advanced research on Alzheimer Disease.

Scientists Uncover Why Some Brain Cells Resist Alzheimer's Disease | Newswise
01/30/2026

Scientists Uncover Why Some Brain Cells Resist Alzheimer's Disease | Newswise

New research by UCLA Health and UC San Francisco has uncovered why certain brain cells are more resilient than others to the buildup of a toxic protein that is a hallmark of Alzheimer’s disease and related dementias, potentially leading to new targets for therapies or treatments.

Scientists Discover Brain-Penetrating Compounds That May Calm Alzheimer’s-Linked Inflammation
01/28/2026

Scientists Discover Brain-Penetrating Compounds That May Calm Alzheimer’s-Linked Inflammation

Researchers have created a targeted compound that blocks an enzyme linked to inflammation in individuals with a genetic predisposition to Alzheimer’s disease, while still maintaining normal brain activity and successfully passing through the blood-brain barrier. Scientists at the University of So

S*x Differences in Alzheimer Pathology in Diverse Cohorts
01/28/2026

S*x Differences in Alzheimer Pathology in Diverse Cohorts

Notable gender and s*x differences have been reported in Alzheimer disease (AD). For example, gender- and s*x-based disparities in risk of AD dementia exist that are not fully accounted for by women’s greater longevity.1 Based on these clinical disparities, we would expect to find gender and s*x.....

An Alzheimer’s breakthrough 10 years in the making — Harvard Gazette
01/28/2026

An Alzheimer’s breakthrough 10 years in the making — Harvard Gazette

The findings mark a potentially major leap in understanding a disease that affects more than 50 million people worldwide.

New Research Suggests Gut Bacteria May Be Linked to Memory Decline in Mild Cognitive Impairment and Alzheimer’s Disease ...
01/23/2026

New Research Suggests Gut Bacteria May Be Linked to Memory Decline in Mild Cognitive Impairment and Alzheimer’s Disease | Media Relations | The George Washington University

A comprehensive new review is shedding light on the growing evidence that gut microbiome imbalances—known as dysbiosis—may play a key role in the development and progression of mild cognitive impairment (MCI) and Alzheimer’s disease, which affects an estimated 6.7 million individuals in the Un...

01/22/2026

Spatial pattern separation deficits in early Alzheimer’s disease are comparable in humans and animal models

Spatial pattern separation (SPS) is a memory process that enables the discrimination of similar spatial locations. This process is vulnerable to pathophysiological changes in the early stages of Alzheimer’s disease (AD), but the translational potential of its testing remains unclear. This study ai...

'Super agers' have genetic advantages against Alzheimer's disease
01/22/2026

'Super agers' have genetic advantages against Alzheimer's disease

New research shows they are less likely to have a gene that increases dementia risk and more likely to have one that may offer protection.

Lessons from the Colombian kindred: rethinking Alzheimer's prevention
01/22/2026

Lessons from the Colombian kindred: rethinking Alzheimer's prevention

In The Lancet Neurology, Pierre N Tariot and colleagues present the Alzheimer's Prevention Initiative (API) Colombia Trial,1 a landmark public–private partnership, evaluating crenezumab in autosomal-dominant Alzheimer's disease (ADAD). The API ADAD Colombia Trial enrolled 252 members of the world'...

Researchers reverse advanced Alzheimer's in mice, paving way for new human trials
01/22/2026

Researchers reverse advanced Alzheimer's in mice, paving way for new human trials

The lead researchers of the study say it represents a fundamental shift in understanding the disease.

A Single Molecule May Explain How Blood Flow in The Brain Triggers Dementia
01/20/2026

A Single Molecule May Explain How Blood Flow in The Brain Triggers Dementia

Reduced blood flow to the brain is thought to be a key factor in many forms of dementia, including Alzheimer's, and scientists have just identified a new mechanism regulating this flow, which may also help explain how it goes wrong.

Researchers to test simple finger-prick blood test to spot early signs of Alzheimer’s - Alzheimer's Research UK
01/20/2026

Researchers to test simple finger-prick blood test to spot early signs of Alzheimer’s - Alzheimer's Research UK

What if screening for the diseases that cause dementia could start with something as quick as a finger-prick blood test?

Increased levels of Alzheimer's-linked protein found in some with long COVID
01/15/2026

Increased levels of Alzheimer's-linked protein found in some with long COVID

A study of 227 individuals who experienced neurocognitive difficulties post COVID-19 infection—such as headaches, vertigo, balance dysregulation, changes in taste/smell, and brain fog—displayed a significant increase in their blood plasma of a crucial protein called tau, which is found in nerves...

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