05/01/2026
Could we stop myeloma before it starts? This is the question driving one of the largest cancer precursor studies in the world and the reason patients will cycle across Iceland this year.
Most people are diagnosed with multiple myeloma after symptoms appear. That can include bone damage, kidney problems, or anemia. But myeloma does not begin overnight.
It starts with an early condition called MGUS. MGUS is not cancer, but it may develop into myeloma over time.
The IMF’s iStopMM study is trying to answer the question: Should we screen people for MGUS or not?
iStopMM stands for Iceland Screens, Treats, or Prevents Multiple Myeloma. It is the largest precursor screening study of its kind. More than 80,000 people in Iceland have taken part. Researchers are tracking what happens when these early signs are found before symptoms begin.
Early findings show that people identified through screening may:
be diagnosed sooner
have fewer bone complications
have less kidney damage
Why this matters
Right now, myeloma is often found after damage has already occurred.
If doctors can find it earlier, they may be able to monitor or treat it sooner. That could change how this disease is managed.
This is promising progress for patients and families who want more options and fewer complications.
How this connects to the Iceland Cycling Expedition
From August 18 to 24, people living with myeloma, care partners, doctors, and supporters, will cycle across Iceland to raise funds for this research.
They are supporting IMF research studies like iStopMM that aim to answer whether myeloma can be detected earlier or even prevented.
Support this year’s cyclists
Every mile supports research. Every donation helps fund studies like iStopMM.
Learn more and support the cyclists: https://icelandcyclingexpedition.org
