01/16/2026
Let’s talk about the 3 phases of liver detoxification. ⤵
Liver detoxification, often referred to as biotransformation, occurs in three distinct phases, collectively known as the hepatic detoxification system.
Understanding this process can empower you to make lifestyle choices that support liver health and reduce exposure to toxins!:
☑️ Phase I (Functionalization):
▪️ Process: In this phase, lipophilic (fat-soluble) substances are metabolized through reactions such as oxidation, reduction, and hydrolysis.
▪️ Role: Converts toxins into intermediate metabolites, often more reactive than the original compounds, preparing them for conjugation in Phase II.
☑️ Phase II (Conjugation):
▪️ Processes: Conjugation reactions involve the addition of water-soluble molecules (e.g., glucuronic acid, sulfate, glutathione) to the intermediate metabolites from Phase I.
▪️ Role: Increases the water solubility of metabolites, making them less toxic and facilitating their excretion from the body.
☑️ Phase III (Transport):
▪️ Processes: Transport proteins, including ATP-binding cassette (ABC) transporters, move the conjugated metabolites and other toxins out of liver cells.
▪️ Role: Transports the water-soluble, conjugated metabolites into bile for elimination through f***s or into the bloodstream for elimination through urine.
These three phases are interconnected and collectively ensure the efficient detoxification and elimination of various substances. The liver coordinates these processes, aiming to protect the body from potentially harmful compounds.
Tell me, were you aware of these three processes? Comment YES or NO below!