02/27/2026
A single fast food meal can trigger inflammation in just 3–5 hours. Here’s how: high saturated fat helps a toxin called LPS — which naturally lives in your gut — slip into your bloodstream. That fat forms transport particles that literally carry LPS across your gut barrier. Once it’s in your blood, your immune system freaks out and releases inflammatory chemicals like TNF-alpha and IL-6. Blood sugar spikes make it worse. One meal won’t ruin you — but if this happens every day, that repeated inflammatory hit adds up fast.