MTHFRDoctor

11/04/2025

Bria’s last two football 🏈 games of the season

01/08/2024

Happiest birthday Hippie! We loved sharing your special day!

02/24/2023

12/13/2022

Are You OVERWEIGHT?
Have you ever felt frustrated that everything you do to lose weight fails? “You know …. You eat clean, exercise, drink your water, eat low carbs, avoid drinking alcohol,”…. Are you estrogen dominant? Have you measured your total estrogen, estradiol, estrone sulfate, progesterone, testosterone, prolactin, T4 T3, TPO anti-thyroglobulin antibodies? Is this hormone imbalance? Could this be stress ? High Cortisol?
First step in weight loss is analyze your hormones. You can use the website Ultalabtest.com which takes you to Quest labs. Extra labs for immune imbalance is Precision Point which can look at the four ways your body can negatively react to food. (Immediate food allergies, immune tolerance, Food sensitivities, autoimmune food reactions) What about gut health? Consider Genesis stool study or Doctors Data stool study. Have you ruled out candidiasis?
So let’s say all of this is normal?
Suggestions:
1. Akermansia probiotic: consider adding this to facilitate weight loss. Make sure to open the probiotic and place into food.
2. Introduce prebiotics too: Xymogen has a great probiomax Df Sb 350 billlion cfu and sprinkle a little bit of this into food daily.
3. If estrogen is dominant: use Estrobalance by Epigeneticsrx.com and Estrofactors by Metagenics.
4. If your menopausal use bioidentical hormones like Vivelle dot and Prometrium or Biest Progesterone Testosterone 1.25 mg (50:50), 25mg, .1% .1ml per va**na qhs.
5. If stressed use Cortisol Manager by Integrative Therapeutics bid
6. If you have Hashimoto’s thyroiditis or autoimmune diseases add LDN 4.5mg qhs
7. Boost metabolism by setting you cell phone alarm to eat plants every 3 hours.
8. If histamine sensitive use Quercitin 500mg bid and follow low Amine diet plus low sulfite diet.
9. Consider using B12 shots weekly with MIC
10. Lastly consider adding GLP-1 meds like Mounjouro or Rybelsus
11. Oh I almost forgot the power of Butyric Acid three times a day. This is a powerful short change fatty acid that has great weight loss.

We offer quick and confidential laboratory testing and health screening services for healthcare professionals and consumers who order blood tests online.

05/27/2019

Do you suffer from Anxiety?
Would you describe yourself as wired and tired? OCD? Type A? Quick to anger or frustration? Need to control situations to prevent chaos? Do you carry the MAOB homozygous genotype? This is found on the X chromosome meaning that all homozygous mothers pass this genotype to their boys. These individuals cannot break down epinephrine quickly. They struggle in chronic excitotoxicity or are over driven in the sympathetic nervous system. They struggle in histamine and catecholamine (epinephrine, dopamine, and norepinephrine) imbalance. They may react to histamine foods and feel reved by excitatory foods like MSG or other amine foods leading to chronic itching, skin disorders, ringing in ears, or irritable bowel. They often have asthma, insomnia, allergies, eosinophilic esophagitis. Suggestions.... to treat anxiety use the beta blocker called Inderal LA. Serotonin drugs may make you feel worse but may work better with a beta blocker. Follow the failsafe diet which is low amines. For GERD anti-histamine drugs like Pepcid AC. For IBS use Molybdenum 300mcg BID and Manganese 10mg bid. For muscle pain or fibromyalgia use Magnesium sulfate 300mg BID. For sleep use pharma GABA And Magnesium Threonate and avoid all amine foods.

10/29/2018

ANXIETY AND FEELING STRESSED 😩 😜 ?? HAVE YOU DONE YOUR 23and ME??
??? COMT VAL158 ++???
Would you describe yourself as a
Worrier and a Warrior or better yet persistently Wired and Tired? If so you may suffer from a common genetic mutation or variant called the COMT Val 158 mutation. This enzyme is involved in critical pathways related to detoxification of estrogens and the breakdown of catecholamines such as Dopamine, Norepinephrine, and Epinephrine as well as other catechol-containing products. The main hang up is the enzyme is super slow! People become excito-toxic with an overwhelming amount of Dopamine and Adrenaline, as well as excess hydroxyl-estrogens. They suffer from an over stimulated sympathetic nervous system. They are chronically stressed and forever tired. These type A overachievers are some of the brightest contributors to society. They pulsate in frontal lobe Dopamine and over think and worry about everything! They are either super joyful or shudder in feeling overwhelmed and never good enough. They are the sensors in our society. They absorb the energy in the room. They are either drained by negative energy and reved up by positive energy. They require their alone time to meditate, pray, relax, or regroup or they burn out! They commonly suffer from estrogen dominance diseases like fibroids, endometriosis, fibrocystic breast, pms, pudding, or prostate disease. They are most at risk during persistent stress, illness, or hormone changes like postpartum or menopause. So how do we treat such individuals?
1. Brain Sustain 1 shake a day made by Xymogen.com (use code BRIGGS)
2. Serentin Plus by Douglas use at bedtime for 2 weeks then switch
3. CalmCP by Neuroscience (use for 2weeks at bedtime then switch back to Serenetin Plus for 2 weeks then keep switching
4. Niacel by Thorne in the am for energy and Methylation balance
5. MethylB12/Methylfolate sub lingual by Xymogen use every other day or hydroxyB12/AdenyB12 by Pure Encapsulation.
6. Omegagenics by Metagenics.com (use code BRIGGSMD)
7. Ultraflora Spectrum as a probiotic by Metagenics
8. Magnesium Sulfate by Dr. Clark on Amazon 1 twice a day
9. Estrofactors 3 Day by Metagenics
10. Low sulfite Diet low Histamine diet as well as gluten and casein free

XYMOGEN is a family-owned health sciences company providing high-quality dietary supplements to licensed healthcare practitioners.

08/10/2018

Are you struggling with Thyroid Disease?
Many of our patients are suffering from autoimmune thyroiditis or from subclinical hypothyroidism and their doctors report their labs are normal. Caution! Is your doctor ordering a complete thyroid panel: TSH, total T4, Free T4, Total T3, Free T3, reverse T3(blocker hormone), TPO antibodies and thyroglobulin antibodies. Thyroid disease is highly related to Estrogen Dominance, Celiac Disease and Gluten intolerance, poor detoxification from BPA found in plastics, low Iodide levels, high Chlorine,Fluoride, or Bromide exposure found abundantly in our drinking water.
What should you consider doing?
1. Order a total Estrogen level and Estrone sulfate with your blood panel. Use Estrofactors and MetaI3C by Metagenics to pull the estrogen down and free up your thyroid. Also add 2 minerals Molybdenum 600mcg 2 x a day and Manganese 10mg a day to pull estrone sulfate down. You should take METHYLCARE by Metagenics to increase methylation as well
2. Add Metagenics Thyrolar which contains all the thyroid stimulation and Rhodiola to block the over production of Reverse T3.
3. Gluten Dairy Free diet
4. Interval fasting means no food until 12pm to 6pm. No cheating and follow the paleoketo diet by Dr. Fong author of the “The Obesity Code”
5. Don’t use artificial sweeteners especially avoid Splenda and aspartame
6. Increase daily detox by drinking Metagenics UltraClear Renew 2x a day and take with Advaclear 2 x a day
7. Sweat in the sauna or hot yoga!
8. Drink Aqua Hydrate alkaline water found in most grocery stores .... between meals not with a meal.
9. Take a powerful Probiotics/prebiotic such as Ultraflora Synergy by Metagenics or ProbiomaxDf Sb by Xymogen. Probiotics MUST TOUCH YOUR TONGUE so open and put in applesauce or a beverage
10. Take high quality Omega 3s like Metagenics Omegagenics not Costco FISH OIL! You take pure omega 3s only!
11. If you want to lose weight you MUST walk on a treadmill or outside for no less than an hour a day to burn your stored sugar in the liver and then start to burn Fat. Your exercise needs to be moderate intensity meaning you can speak but it feels difficult to carry on a conversation.

Good Luck!🍀👍🏻

Your MTHFRdoctor
Metagenics is available on-line
access code: BRIGGSMD should give you access to my physician discount! Enjoy 😉

02/01/2015

Are Phenols Making You Sick? http://wp.me/p5xNmW-V

Today many individuals are suffering from phenol toxicity. Many of these phenols are naturally found in foods such as fruits and vegetables, but more importantly they are ubiquitously found in various chemicals, plastics, fuels, and pesticides. While I believe that we are all suffering from excess exposure to synthetic phenols, there are certain individuals who cannot adequately detoxify and remove the chemical byproducts of these insults. [ 471 more words. ]

01/11/2015

If Fibromyalgia Related to Sulfites?

In clinic we are seeing a growing patient population with fibromyalgia and chronic fatigue. Fibromyalgia is characterized by a number of point areas of muscle tenderness throughout the body. Through genomic results, it has become apparent that many of these patients have an up-driven trans-sulfuration pathway in the body. That means that in many patients when the body lacks the ability to use folate in its fullest, the body will rely more heavily on a secondary pathway called the trans-sulfuration pathway. This pathway, while processing sulfur-containing amino acids, can lead to an excessive production of sulfites. Sulfites naturally lead to an excessive production of acidic cofactors, increasing an acidic burden on the body and depleting the body of essential minerals such as molybdenum, manganese, magnesium, and many other critical minerals. Many of our fibromyalgia patients find great relief of their muscle pain and body aches when we place them on a multivitamin/mineral such as Mitofuel, which contains methylated B vitamins and higher dosages of critical minerals and anti-oxidants. We also often use strong alkalinizing approaches such as can be achieved by drinking alkaline mineral waters, such as Aquahydrate or alkalinizing medical foods such as UltraClear Renew by Metagenics in combination with Sulfite XX which is simply an extra dosage of molybdenum and manganese- chelated minerals at two meals of the day. This approach appears to help clear sulfites more quickly while helping to better produce healthier sulfates used by the liver for Phase II detoxification. Could it be that fibromyalgia is a syndrome of excess sulfites, an acidic burden, and impaired detoxification? To date, there is no known single gene related to the development of fibromyalgia, but we do see common hereditary links in our patient population.

Please visit EpigeneticsRX.com for further information about nutrient support.

Bridget Briggs, M.D

01/05/2015

A lot of doctors and clinicians believe that this is old news. Yah, Yah they say.... all you have to do is just give people with the MTHFR mutation methylfolate right. I mean how hard can this be? Well, I can tell you as an experienced clinician..... blindly prescribing methylfolate can make a lot of people sick. I literally saw people take massive dosages of methylfolate and methylB12 develop a whole hose of other problems. The methylfolate cycle is connected to a number of other cycles in the body such as the urea cycle, the biopterin cycle, and the tran-sulfuration cycle. I watched people over ingest methyl groups which caused joint pain, tendinitis, bursitis, Small intestinal bacterial overgrowth, heart burn, allergies, itchy skin....all of these side effects were a result of the over production of sulfites in the body via the up-regulation of the transulfuration pathway. In essence, when certain individuals over consume too much methylfolate they can increase the production of sulfur containing metabolites and amino acids in the body. Sulfur is important in protein structural support and has a tendency to make proteins spin or turn. This includes keratin protein which in found in hair and nails. Therefore, I have seen patients over-methylate and therefore develop longitudinal lines in their nails and create waves or curls in the hair, or increase sulfur containing hormones in their blood such as estrone sulfate or DHEAsulfate. Whereas curly hair has never made people sick, but the same can occur to tendons and fascia creating plantar fasciitis, tendonitis, or bursitis. Many people who complain of fibromyalgia type of pain or joint pain are actually experiencing an excess of sulfites in the body and would benefit from taking Sulfite XX twice a day. This mineral cocktail helps people clear sulfites and produce healthy sulfates. Sulfites are pro-inflammatory and toxic as compared to sulfates which are critical to joint and tendon strength and critical for phase II liver detoxification. Sulfates support a healthy Gut barrier and Blood brain barrier, as well as bronchial and vascular dilation. This is why we treat bronchial constriction such as seen in asthma with albuteral sulfate and this is why we can treat joint and muscle pain with magnesium sulfate found in Epsom Salt baths.

12/31/2014

The enzyme MTHFR, also known as methylene tetrahydrofolate reductase, is the critical enzyme in the human body essential for the activation of folate to the methylated form of folate called L-5MTHF. This L-5MTHF is critical in several biochemical steps involved in human metabolism. It is critical in detoxification, hormone balance, tumor or cancer prevention, cell growth, and neurotransmitter synthesis. The enzyme mutation known as MTHFR C677T or MTHFR A1298C can be found in up to 40% of Americans, although it is found worldwide. This simple enzyme defect can be easily treated with a special form of folic acid called methyl folate.

Millions of Americans who suffer from chronic disease, mental disorders, and hormone imbalance are seeing positive life changes after the simple ingestion of the correct form of folate.

Ask your doctor to test you for the MTHFR genetic mutation