06/26/2025
What is SPRAVATO® (esketamine)?
SPRAVATO® (Esketamine Nasal Spray)
How it works:
Esketamine targets glutamate, a brain chemical involved in mood regulation. It works faster than most traditional antidepressants, with patients often seeing improvement within the first few treatments
What to expect:
▪️Urine drug screening required prior to treatment
▪️Administered in our clinic under provider supervision
▪️Patients will be monitored for 2 hours by staff, with intermittent blood pressure checks
▪️Sessions begin as 2 times/week for the first month, then once weekly for the second month, then once every 2 weeks or once monthly for maintenance if recommended based on treatment response
▪️Due to sedative effects, designated driver is required to and from each appointment
Side effects:
▪️Dizziness, nausea, sedation, dissociation (feeling detached from reality)
▪️Short-term increase in blood pressure
Not recommended in patients with:
▪️Active substance use or abuse
▪️Aneurysmal vascular disease (including thoracic and abdominal aorta, intracranial and peripheral arterial vessels) or arteriovenous malformation.
▪️History of intracerebral hemorrhage.
▪️History of hypersensitivity to esketamine, ketamine, or related.
Pauleana Stevanovski, PA-C