The New England Journal of Medicine

11/08/2025

An 83-year-old man presented to the ED with generalized pruritus that had begun the previous night. One month earlier, he had been evaluated in the neurology department for a unilateral peripheral facial-nerve palsy.

11/07/2025

In the latest episode of the Not Otherwise Specified podcast, host Lisa Rosenbaum, MD, and her guests explore the fraught relationship between medical training and primary care — and why even trainees who once aspired to be PCPs are changing course midstream.

11/07/2025

A 20-year-old man with Graves’ disease presented to the ED with a 2-hour history of confusion. A goiter, bounding carotid pulses, and bruits over the thyroid (shown in videos) were noted on physical examination.

11/06/2025

Opioid deprescribing is advised when risks of opioid use outweigh benefits. A tailored, patient-centered plan with gradual dose reduction, monitoring, and support can improve outcomes and reduce harm.

11/05/2025

“Ah, it's your first gastroenteritis. It gets easier.”

The latest video in our partnership with Dr. Glaucomflecken summarizes recent research on the effects of ondansetron after emergency visits in children with gastroenteritis-associated vomiting.

Get free access to the article: https://nej.md/DrG29

11/04/2025

In NEJM Journal Watch, Dr. Hana El Sahly comments on a study that examined the effectiveness of the two-dose recombinant zoster vaccine regimen among Medicare beneficiaries.

Real-World Performance of Zoster Vaccine

The recombinant zoster vaccine was effective among Medicare beneficiaries regardless of prior vaccination status. https://jwat.ch/4hxX0Ho

11/04/2025

A previously healthy man presented with a 10-day history of blood dripping from one nostril. Twenty days earlier, he had washed his face with mountain spring water. A leech was found on nasal endoscopy (shown in a video).

11/03/2025

Case Record of the Massachusetts General Hospital: A 56-year-old man was admitted to MGH because of left lower abdominal pain and anemia.

The patient had been in his usual state of health until 1 year before the current presentation, when diarrhea developed. The stools were watery, foamy, and nonbloody. The diarrhea was worst after he had eaten, although it did not fully resolve with fasting. It occasionally woke him up from sleep and was associated with bloating but no pain, nausea, or vomiting.

11/02/2025

A 30-year-old man presented with recurrent, painful vesicles on his left lower eyelid. Clustered, umbilicated erosions and ulcers were found on an erythematous base on the medial aspect of the lower eyelid margin.

11/01/2025

A 1-week-old full-term baby boy was brought back to the hospital with discharge from his navel. Physical examination showed pink tissue at the umbilicus that seeped yellow liquid. Abdominal ultrasonography was performed. What is the underlying pathophysiology? https://nej.md/IC10302025

10/31/2025

In the latest episode of the Not Otherwise Specified podcast, Dr. Lisa Rosenbaum and her guests consider the ideals and realities of primary care — and the expectations and misunderstandings that are contributing to its current crisis.

10/31/2025

The prognosis of liver disease depends on the extent of fibrosis, which is usually staged with the use of liver biopsy. The limitations of biopsy have led to the development of noninvasive tests, which Drs. Laurent Castera, Mary E. Rinella, and Emmanuel A. Tsochatzis review.