The New England Journal of Medicine

11/29/2025

In low-risk patients with MI and early complete revascularization, stopping aspirin after 1 month and continuing P2Y12 monotherapy was noninferior to dual antiplatelet therapy for ischemic outcomes and led to reduced bleeding at 1 year.

11/28/2025

A 5-year-old boy was admitted to the hospital because of fever and rash. Nonblanching papules spread from the feet to the legs, buttocks, lower back, arms, and ears. A diagnostic test was performed. What is the most likely diagnosis in this case?

11/28/2025

In the latest episode of the Not Otherwise Specified podcast, host Lisa Rosenbaum, MD, and her guests lay bare the joys and rewards of full-spectrum primary care practice and consider ways of stoking students’ passion, and strengthening their ability, to pursue it.

11/27/2025

For a man hospitalized for uncomplicated diverticulitis who is found to have high blood pressure, would you support watchful waiting or recommend inpatient treatment of the high blood pressure?

11/26/2025

A 26-year-old woman was referred to the pulmonary hypertension clinic with a 6-month history of exertional dyspnea and hoarseness. Vocal-fold paralysis was seen on laryngoscopy (shown in a video).

11/25/2025

Coming soon...

11/25/2025

In patients with cardiovascular disease and an implantable cardioverter–defibrillator, increasing potassium levels to the high-normal range reduced the risk of arrhythmia events, hospitalizations, and death.

11/24/2025

In NEJM Journal Watch, Dr. Paul Sax offers some thoughts on when AI gets medical advice wrong — and right.

Dr. Paul Sax tested two AI tools and found that one repeated a common medical misconception — but so did a human clinician quoted in the media. Read his take, in the latest HIV and ID Observations. https://jwat.ch/3K6h8US

11/24/2025

Joshua A. Boyce, MD, describes two studies implicating intestinally generated cysteinyl leukotrienes in food anaphylaxis.

11/23/2025

A 75-year-old woman with a history of breast cancer treated with mastectomy of both breasts and adjuvant hormonal therapy presented with a 1-year history of a rash on her chest.

11/23/2025

What are the challenges of recommending bisphosphonates to patients who have normal bone density? Dr. Ann Garment, chief of general internal and hospital medicine at Bellevue Hospital in New York (NYC Health + Hospitals), discusses this in the latest episode of Beyond Journal Club, a collaboration between CORE IM and NEJM Group.

11/22/2025

A new article in NEJM Catalyst reports the results of a pilot randomized controlled trial exploring the link between receiving a preferred safety device and a change in firearm-storage behavior. The results suggest that the Penn Medicine program that distributes free firearm locking devices to patients may contribute to increased adherence to gun safety practices.