The Ruesch Center for the Cure of Gastrointestinal Cancers

The Ruesch Center for the Cure of Gastrointestinal Cancers Combining expertise in molecular medicine, translational research, and a patient-centered philosophy We cannot give up the war on cancer.

Finding a Cure

The original charge in declaring war on cancer by Richard Nixon in 1971 was "an appropriation of an extra $100 million to launch an intensive campaign to find a cure for cancer." Yet after many billions of dollars and nearly 40 years of research, we have only cured a handful of rare cancers. The most common cancers, including breast, prostate, lung, and the GI cancers, remain deadly and feared diseases with only limited advances in treatment. Molecular Medicine
Because of our lack of understanding of the molecular biology of cancer and the overwhelming variability in cancers and patients, we abandoned the original charge to cure cancer and adopted a strategy to try simply to extend survival. While we have been able to achieve some improvements in survival, these are modest at best, are unbelievably expensive, and force patients to endure great physical and emotional burdens. Dramatic improvements in molecular biology have lead to a better understanding of what makes cancers "tick", new anti-cancer agents are being developed at an unprecedented pace, new technologies allow us to measure the many variables quickly and accurately, and improvements in bio-informatics allow us to analyze the resulting data sets. These improvements are the foundation of personalized medicine, the only way forward in the quest to cure cancer. This is the charge of the Ruesch Center.

Bring twice the hope in 2025. During this season of gratitude, we thank you for your continued engagement and support of...
12/15/2025

Bring twice the hope in 2025. During this season of gratitude, we thank you for your continued engagement and support of the Ruesch Center for the Cure of Gastrointestinal Cancers. Make your impact today—a generous supporter will match every donation dollar‑for‑dollar, up to $25,000, through Dec 31, 2025. Visit bit.ly/RueschGiving25 to double your support for transformative GI Cancer research at Lombardi Comprehensive Cancer Center.

On November 20th, we were honored to present a Luminary Award in GI Cancers to Carolyn R. ("Bo") Aldigé, Founder of Prev...
12/02/2025

On November 20th, we were honored to present a Luminary Award in GI Cancers to Carolyn R. ("Bo") Aldigé, Founder of
Prevent Cancer Foundation.

"Bo Aldigé has been a true catalyst for cancer prevention and early detection, profoundly shaping the field over the past four decades. Her unwavering commitment shone a light not only on colorectal cancer prevention and early detection but also on all cancers, inspiring countless advocates and professionals to prioritize these vital conversations. We are deeply thankful for the fire she lit forty years ago—a spark that continues to encourage the field to keep prevention and early detection at the forefront, improving and saving lives across the world," said Jody Hoyos, CEO of Prevent Cancer Foundation.

Lombardi Comprehensive Cancer Center OncLive

Today is  ! Your generous gift is essential to fuel the Ruesch Center’s work—asking the tough questions, embracing bold ...
12/02/2025

Today is ! Your generous gift is essential to fuel the Ruesch Center’s work—asking the tough questions, embracing bold ideas, and leading the way toward identifying new and improved therapies for GI cancers. Thank you for your support. bit.ly/RueschGiving25

https://youtu.be/TXPn6CU-Z90

Dino D'Agata discusses the support he's received through Georgetown's Lombardi Comprehensive Cancer Center, physicians, nurses, and the community during his ...

Tomorrow is Giving Tuesday! Learn more about the value of funding research at the Ruesch Center at Lombardi Comprehensiv...
12/01/2025

Tomorrow is Giving Tuesday! Learn more about the value of funding research at the Ruesch Center at Lombardi Comprehensive Cancer Center during the season of support. Your generous gift is essential to fuel the Ruesch Center's work, which involves asking tough questions, identifying bold ideas, and leading efforts to develop new and better therapies for GI cancers. Thank you!

Join The Ruesch Center for the Cure of Gastrointestinal Cancers during our Season of Support!

Last week, we were honored to present a Luminary Award to Scott Kopetz, MD, PhD, FACP of MD Anderson Cancer Center.  Dr....
11/25/2025

Last week, we were honored to present a Luminary Award to Scott Kopetz, MD, PhD, FACP of MD Anderson Cancer Center. Dr. Benjamin Weinberg shared why his colleague, Dr. Kopetz, is so deserving of this award. "Scott Kopetz has revolutionized the treatment of patients with BRAF-mutated metastatic colorectal cancer. This roughly 10% of patients have an astoundingly poor prognosis and do not derive as much benefit from standard chemotherapy as patients without BRAF mutations. Through a true bench-to-bedside and back again approach, he showed that adding a BRAF inhibitor pill to a commonly used colorectal cancer drug Cetuximab, was superior to standard chemotherapy for patients who had had prior treatments. He took this a step further, showing that adding these targeted therapies to chemotherapy is superior to targeted therapies or chemotherapy alone in patients who had not had prior treatments. Most recently, he showed a potential benefit of adding immunotherapy to targeted therapy in this population."

11/25/2025

From the Desk of Louis Weiner, MD, Director of the Lombardi Comprehensive Cancer Center.
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'Greetings on a fairly nice autumn weekend. Last week was highlighted by a brief short-notice visit from the Karolinska Institutet. But what I’ll remember moving forward was the Ruesch Center events that followed later that week.

Led by John Marshall, the Ruesch Center now functions as the home of our GI Cancer Working Group. On Thursday afternoon, we had a strategic retreat of that working group, with about 60 attendees spanning all GI cancer-relevant disciplines, including a strong surgery contingent, hospitals in D.C., and people based in New Jersey as well. There were some general talks, with three very vibrant and impactful disease-focused breakout groups. It was a truly invigorating and interesting event.

That evening, we repaired to the Riggs Library on campus for the GI Luminary Awards. The awardees were Katie Couric, TV journalist and co-founder of the nonprofit Stand Up To Cancer; Carolyn “Bo” Aldigé, who founded the Prevent Cancer Foundation; Anil Rustgi, director of the Herbert Irving Comprehensive Cancer Center at Columbia University; Scott Kopetz, a GI medical oncologist from MD Anderson Cancer Center; and Margaret Tempero, a renowned pancreatic cancer researcher at UCSF. I had the privilege of introducing Margaret, an old friend and colleague, and we shared anecdotes about each other from the old days. It was a marvelous evening.

Friday marked the start of the annual Ruesch Symposium at 2115 Wisconsin Avenue. It was a simply marvelous meeting, rich with talks and interactions. Then the patient-facing event was held on Saturday. I was unable to attend the latter event, but if it was anything like the two days that preceded it, it was great as well.

We all get caught up in the chaos of our day-to-day lives, but sometimes it is very helpful to stop, take stock, and marvel at what is being accomplished. Starting with an idea 20 years ago, and with the generous support from the Ruesch Family Foundation and other donors, the Ruesch Center for the Cure of Gastrointestinal Cancers has evolved into a genuine force at the national and international levels. Its members certainly talk about science, patient care and population impact, but they also walk the walk and lead the way.

In case you have not yet figured this out, John Marshall is an absolute treasure who exemplifies all that is great about Georgetown University and the Lombardi Comprehensive Cancer Center. He has made this progress happen through the force of his intellect, his unwavering focus, and just enough honey (with a hint of bourbon) to be the driver of all this progress. We are lucky to call him our own.

Be like John. Make the world a better place this week.'

Lou

Categories Weekly post Convening Post author By Dr. Louis M. Weiner Post date November 23, 2025 Greetings on a fairly nice autumn weekend. Last week was highlighted by a brief short-notice visit from the Karolinska Institutet. But what I’ll remember moving forward was the Ruesch Center events that...

We are thrilled to be gathered with GI Cancer patients, advocates, caregivers and survivors for the second day of the   ...
11/22/2025

We are thrilled to be gathered with GI Cancer patients, advocates, caregivers and survivors for the second day of the .

Thrilled to kick off the 2025   featuring incredible GI Cancer faculty from University of Maryland, Johns Hopkins, Inova...
11/21/2025

Thrilled to kick off the 2025 featuring incredible GI Cancer faculty from University of Maryland, Johns Hopkins, Inova and Lombardi Cancer.

'Edward M. KovachKovach (C’57, L’60) earned his undergraduate and law degrees from Georgetown, served as an officer in t...
11/17/2025

'Edward M. KovachKovach (C’57, L’60) earned his undergraduate and law degrees from Georgetown, served as an officer in the U.S. Coast Guard, and practiced labor law in San Francisco for several decades. He also met his wife of more than 50 years at Georgetown, and together they had five children.

Alex Kovach speaks from the podium in Gaston Hall
Alexandra Kovach du Pont “He led an interesting, fulfilling and fortunate life, and he was appreciative of every moment,” said his daughter, Alexandra Kovach du Pont. “And then, in 2014, he finds himself back at Georgetown, diagnosed with Stage 4 pancreatic cancer.”

Throughout his treatment with John Marshall, MD, director of the Ruesch Center for the Cure of Gastrointestinal Cancers at Georgetown Lombardi, Kovach was treated as not just a patient but a whole person, Kovach du Pont said. Inspired by the care he received, they decided to create the Kovach Lecture.

“This beautiful concept of cura personalis, how we care for one another, patients and doctors in both directions, as full people listening to each other, asking questions, taking time to check in, these are the things that make a difference,” Kovach du Pont said.'

The Edward M. Kovach Cura Personalis Endowed Lecture featured Anthony Fauci, MD, in conversation with CBS News' Norah O’Donnell.

More memories from an incredible BellRinger event! Thank you to the riders, volunteers, and supporters for your commitme...
11/15/2025

More memories from an incredible BellRinger event! Thank you to the riders, volunteers, and supporters for your commitment to funding critical research at the Lombardi Comprehensive Cancer Center. http://bit.ly/RueschBellRinger

In this week's publication search, Dr. John Marshall highlighted research published in . Learn more about this study.
11/15/2025

In this week's publication search, Dr. John Marshall highlighted research published in . Learn more about this study.

Dr. John Marshall discusses recent compelling research published in Nature. https://pubmed.ncbi.nlm.nih.gov/40267983/. To view this week's full publication s...

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