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Patient-Centered Outcomes Research Institute - PCORI

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Patient-Centered Outcomes Research Institute - PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

12/17/2025

A PCORI-funded patient-centered CER study compared outcomes for 2 common treatments for aortic valve disease:

◻️ Transcatheter aortic valve replacement (TAVR), which requires no major surgery.
◻️ Surgical aortic valve replacement (SAVR), which typically involves open-heart surgery.

Results showed TAVR recipients were more likely to go directly home after treatment and less likely to go somewhere else for care than SAVR recipients. Read more: https://pcori.me/4aAoUkX

12/16/2025

Today, PCORI announced funding awards for new patient-centered CER studies addressing a range of health concerns.

◽11 new patient-centered CER studies addressing a range of pediatric and adult health challenges
◽8 studies advancing CER methods, including strategies for meaningful patient and stakeholder engagement
◽1 project supporting the implementation of PCORI-funded CER findings into real-world clinical settings

Learn more about the newly funded awards: https://pcori.me/4pJCgzU

12/15/2025

PCORI’s Engagement in Health Research Literature Explorer database offers streamlined access to nearly 2,000 citations for peer-reviewed articles about engagement in health research!

Filters allow you to quickly find articles on a range of topics, including studies that explore collaboration with patients, caregivers and the broader healthcare community and research involving specific health conditions.

Access the Literature Explorer: https://pcori.me/4hc21os

12/12/2025

In a PCORI-funded study, 2 approaches for treating adults with chronic migraines and medication overuse were compared.

While the 2 approaches worked about the same to reduce the number of days per month with a migraine, compared to people who continued taking the overused medicine, individuals who stopped taking the overused medicine:
◼️ Had fewer days when they used medication to relieve symptoms
◼️ Were less likely to overuse medication

These results can assist individuals and their clinicians in managing migraine pain and avoiding medication overuse. Learn more: https://pcori.me/3oRC18z

12/11/2025

Primary care clinicians are often the first point of contact for people seeking medical advice, preventative services or treatment for common health conditions. They play a critical role in diagnosing and treating a wide range of conditions and coordinating referrals to specialists when needed. Despite their central role, many questions remain about which treatment options are most effective within primary care settings.

Discover how PCORI is helping to close these knowledge gaps via patient-centered CER. https://pcori.me/48SqqfG

12/10/2025

The latest edition of PCORI’s Emerging Health Care Innovation Brief highlights FDA approval of a treatment for a type of relapsed or refractory acute myeloid leukemia and the FDA’s acceptance of a biologics license application to treat wet age-related macular degeneration.

Other topics to watch include:
✔️ DoxTM (Kygevvi), an oral nucleoside therapy designed to treat an ultrarare, progressive primary mitochondrial myopathy
✔️ Ribitol (BBP-418), an oral supplementation therapy intended to treat limb-girdle muscular dystrophy

Read more: https://pcori.me/48HjUbl

12/09/2025

New Funding Opportunity: Retrospective Observational CER on Select PCORI Topic Themes 📢

Learn more about this unique PFA that seeks to support well-designed, methodologically robust, retrospective observational patient-centered CER in a virtual Town Hall happening tomorrow at Noon (ET).

Register here: https://pcori.me/4oXTk4G

12/08/2025

Learn more about The Cancer Partner PFA in tomorrow's Town Hall!

This PFA requires a dual principal investigator structure who will share leadership equally throughout the study:
✔️ PI from a research organization
✔️ PI from a community organization

Register for the Town Hall: https://pcori.me/4nYraVW

12/05/2025

Is PCORI Funding a Fit for Your Research Idea?

Use PCORI’s decision tool to help assess whether your research idea aligns with one of PCORI’s patient-centered CER funding opportunities.

Review the decision tool: https://pcori.me/3JCiOFi

12/04/2025

🚑 A PCORI-funded patient-centered CER study compared mobile stroke units (MSUs) to standard ambulance transport to the emergency room.

Findings showed that individuals transported by MSUs received treatment 36 minutes faster on average and were more likely to recover from a stroke without disability, highlighting the life-changing potential of faster pre-hospital stroke treatment.

Read more: https://pcori.me/41H9IMO

12/03/2025

The latest edition of PCORI's Emerging Health Care Innovation Brief highlights new draft guidance from the FDA for biosimilar drugs, as well as recent FDA approvals for treatments addressing a rare mitochondrial disease and a rare eye disorder.

Topics to watch include:
◻️ DB-OTO, a one-time gene therapy to treat OTOF-related hearing loss.
◻️ Dexmedetomidine (Igalmi), an under-the-tongue treatment for agitation in schizophrenia or bipolar disorder.

Explore emerging therapies: https://pcori.me/48vcms6

12/02/2025

PCORI is now accepting Letters of Intent for several PCORI Funding Announcements!

These PFAs are designed to advance patient-centered CER — research that compares the benefits and potential harms of different treatment options to help patients, caregivers and the broader healthcare community make informed healthcare decisions.

Take advantage of this opportunity to advance patient-centered CER and prepare your LOI for submission. https://pcori.me/49M0dBv

Address

1333 New Hampshire Avenue Suite 1200
Washington D.C., DC
20036

Opening Hours

Monday	8:30am - 5:30pm
Tuesday	8:30am - 5:30pm
Wednesday	8:30am - 5:30pm
Thursday	8:30am - 5:30pm
Friday	8:30am - 5:30pm

Website

http://www.pcori.org/

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