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Monday 8:30am - 5:30pm Tuesday 8:30am - 5:30pm Wednesday 8:30am - 5:30pm Thursday 8:30am - 5:30pm Friday 8:30am - 5:30pm

Patient-Centered Outcomes Research Institute - PCORI

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Patient-Centered Outcomes Research Institute - PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

01/16/2026

Now Open: Draft Questions for Systematic Review on Psychosis and Psychotic Disorders in Youth

PCORI seeks your input on the draft key questions that will define the scope of this review. Your insights will help ensure the review addresses important issues related to psychosocial interventions for psychosis and psychotic disorders among youth.

Submit feedback by Feb. 12: https://pcori.me/4pGTj4C

01/15/2026

1️⃣ Week Away: Addressing Sensory Health Needs Across the Lifespan Preannouncement Town Hall

This webinar will provide an overview of the PFA and offer an opportunity to engage directly with program staff. This session is designed to help researchers shape competitive Letters of Intent.

Register for the Town Hall: https://pcori.me/49wNd0N

01/14/2026

Join PCORI leadership and members of the healthcare community for the annual PCORI 2026 & Beyond webinar!

🗓️ Thursday, Feb. 5
🕰️ 2:30 pm (ET)

Be among the first to hear what’s next at PCORI!

Submit your questions during registration to make the most of your virtual experience. Register here: https://pcori.me/4rdCxvt

01/13/2026

What does it take to power patient-centered research at a national scale?

A new special issue of Medical Care takes an in-depth look at PCORnet®—highlighting how its federated infrastructure supports patient-centered CER, drives innovation and enables high-impact research across the country.

Learn more & access the journal here: https://pcori.me/49BAVEz

01/12/2026

This latest edition of PCORI’s Emerging Health Care Innovation Brief spotlights FDA approvals for:

◼️ Gene therapy for Wiskott-Aldrich syndrome, a rare genetic immunodeficiency
◼️ Chimeric antigen receptor T-cell therapy for marginal zone lymphoma
◼️ Hematopoietic stem cell transplant therapy for severe aplastic anemia

Other topics to watch include an experimental, polymer-based patch for early oral cancers and ropeginterferon alfa-2b for essential thrombocythemia, a rare blood cancer.

Read more: https://pcori.me/4qGyHKI

01/09/2026

Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral condition affecting how children and teens pay attention, stay focused and control their behavior — often creating challenges at home, at school and with peers.

A recent evidence review looked at available diagnostic tests and treatment options for children and teens with ADHD.

Discover what the research reveals about effective ways to diagnose and treat ADHD — and how this evidence can help inform better care decisions for young people. https://pcori.me/49o2q4c

01/08/2026

🆕 Cycle 2 2026: Addressing Sensory Health Needs Across the Lifespan

Join PCORI for a preannouncement webinar on this PFA, which seeks to fund high-quality patient-centered CER projects focused on advancing care and outcomes across the lifespan for people living with sensory health conditions.

Learn more & register: https://pcori.me/49wNd0N

01/07/2026

Applications Open: PCORI Advisory Panel

PCORI is seeking applications and letters of support for open advisory panel positions. Advisory panels are one way PCORI brings valuable perspectives from the healthcare community into PCORI's work.

Learn more: https://pcori.me/3LsMO2Z

01/06/2026

A recent edition of PCORI's Emerging Health Care Innovation Brief highlights the second FDA-approved treatment for familial chylomicronemia syndrome and FDA approval of another gene therapy for spinal muscular atrophy.

Other topics to watch include:
◼️ Daraxonrasib (RMC-6236), an oral small-molecule drug designed to treat the most common form of pancreatic cancer.
◼️ Ozekibart (INBRX-109), an experimental antibody therapy developed to treat unresectable or metastatic rare, malignant and cartilage-producing tumors.

Read more: https://pcori.me/49aLBel

01/05/2026

Closing Tomorrow: Submit Your Letter of Intent!

Take the first step toward funding your next patient-centered CER study idea by submitting your LOI for PCORI's latest funding opportunities.

LOIs are due Tuesday, Jan. 6, at 5 pm (ET). Learn more & submit: https://pcori.me/49M0dBv

01/02/2026

A PCORI-funded patient-centered CER study compared 2 non-drug treatments: mindfulness-based therapy (MBT) and cognitive-based therapy (CBT) to help adults with opioid-treated chronic low back pain reduce pain severity and opioid dose and improve quality of life.

After 1 year, the pragmatic randomized controlled trial found that adults receiving MBT and CBT had:
✔️ Improved pain levels and quality of life
✔️ Better ability to do daily activities
✔️ Reduced daily opioid medicine use

Read more about the study: https://pcori.me/4mQYNZq

12/31/2025

As we approach the close of another meaningful year, PCORI wants to take a moment to express deep appreciation to the patients, caregivers and the broader healthcare community for your many contributions in advancing PCORI's mission.

Sharing gratitude and wishing you a happy new year!

Address

1333 New Hampshire Avenue Suite 1200
Washington D.C., DC
20036

Opening Hours

Monday	8:30am - 5:30pm
Tuesday	8:30am - 5:30pm
Wednesday	8:30am - 5:30pm
Thursday	8:30am - 5:30pm
Friday	8:30am - 5:30pm

Website

http://www.pcori.org/

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