Patient-Centered Outcomes Research Institute - PCORI

04/24/2026

The final report for the PCORI-commissioned systematic review on Medical Care for Adults With Down Syndrome is now available.

This review examines the evidence on screening, diagnosis and treatment of co-occurring health conditions for individuals with Down syndrome. Read more: https://pcori.me/47cLjmj

04/23/2026

Rigorous methodology standards support more credible and useful evidence, which can inform healthcare decision making.

As part of its ongoing efforts to refine these standards, PCORI is seeking public comment on a comprehensive update to its Methodology Standards for patient-centered CER.

Take advantage of this opportunity to help shape the conduct of patient-centered CER! https://pcori.me/4tiK65r

04/22/2026

A PCORI-funded randomized controlled trial compared two approaches to providing prenatal care and opioid use disorder (OUD) treatment:

1️⃣ Collaborative Care Model: Clinicians received four to six training sessions on OUD treatment, medications and counseling, while a clinical care coordinator helped women attend their prenatal visits and supported their recovery

2️⃣ Extension for Community Healthcare Outcomes: Clinicians joined regular video sessions with an OUD treatment expert to discuss care and guidance options

Read the results: https://pcori.me/4sSvwjX

04/21/2026

Open Research Funding Opportunities: Letter of Intent Submissions Due in One Week!

Submit Your LOI for the Following PFAs:
◾ Addressing Sensory Health Needs Across the Lifespan
◾ Phased Large Awards for Comparative Effectiveness Research
◾ Broad Pragmatic Studies
◾ Advancing the Science of Engagement in Research
◾ Improving Methods for Conducting Patient-Centered CER

Learn more: https://pcori.me/3QjqU90

04/20/2026

Kidney stones affect approximately 1 in 9 Americans adults — and rates in children are climbing.

A final report for the PCORI-commissioned systematic review — Recurrent Nephrolithiasis in Adults and Children: Comparative Effectiveness of Preventive Medical Strategies — is now available.

This review examines evidence on medical approaches to help prevent kidney stones from recurring in both adults and children.

Read more: https://pcori.me/4llc8IO

04/17/2026

PCORI’s Engagement in Health Research Literature Explorer database offers streamlined access to nearly 2,000 citations for peer-reviewed articles about engagement in health research!

Filters allow you to quickly find articles on a range of topics, including studies that explore collaboration with patients, caregivers and the broader healthcare community and research involving specific health conditions.

Access the Literature Explorer: https://pcori.me/4hc21os

04/16/2026

The latest edition of PCORI’s Emerging Health Care Innovation Brief spotlights two medical devices that received FDA premarket approval: the transcatheter Trilogy Valve for severe aortic regurgitation and the aura6000 system for obstructive sleep apnea.

Other highlighted topics include:
◻️ Cebranopadol, an experimental analgesic for treating moderate to severe acute pain
◻️ FemBloc, an investigational, nonsurgical and in-office permanent contraception procedure.

Explore emerging therapies: https://pcori.me/4cm5u3L

04/15/2026

Apply To Be a Merit Reviewer at PCORI!

PCORI is seeking scientists, patients and individuals from across the broader healthcare community to evaluate applications submitted for PCORI funding.

As a merit reviewer, you can help:
◼️ Assess research funding applications through a rigorous scientific evaluation
◼️ Confirm proposed projects are patient centered and relevant to real-world needs
◼️ Shape the future of patient-centered CER

Learn more & apply: https://pcori.me/3Nv2jt8

Home Funding Opportunities Merit Review Become a Merit Reviewer Become a Merit Reviewer Merit Review Merit Review Process Meet Our Merit Reviewers Become a Merit Reviewer Merit Review Mentor Program Merit Reviewer FAQs Image PCORI’s merit review process is distinguished by the participation of sci...

04/14/2026

Today, PCORI, in collaboration with the Bipartisan Addiction Treatment and Recovery Caucus, hosted a Substance Use Disorder (SUD) Briefing on Capitol Hill.

Researchers from across the country discussed PCORI-funded patient-centered CER comparing approaches to improve outcomes for people with opioid or SUD.

04/13/2026

Provide Your Input for an Upcoming Systematic Review: Removal of Myomas in Asymptomatic Patients To Improve Fertility or Reduce Miscarriage Rate

Your input on the draft key questions will help define the scope of this review and help ensure it addresses the issues related to this important topic.

Submit your input by tomorrow at 5 pm (ET): https://pcori.me/4rIN2GB

04/10/2026

Now Open: 2026 PCORI Annual Meeting Scholarship

PCORI offers a select number of scholarships for patients, caregivers and members of community-based organizations, covering domestic travel and lodging expenses incurred by attending the PCORI Annual Meeting.

Apply for a scholarship to attend in Washington, D.C., Oct. 20-21! https://pcori.me/4vpWS3A

04/09/2026

The Advancing the Science of Engagement in Research PFA seeks to fund studies that build an evidence base on engagement in research, including:

◼️ Measures to capture structure/context, process, and outcomes of engagement in research
◼️ Techniques that lead to effective engagement in research
◼️ How effective engagement techniques should be modified and resourced for different contexts, settings, and communities

Register here for tomorrow's Town Hall: https://pcori.me/4lIo8FO