JACC Journals

12/21/2025

A 44-year-old heavy smoker from the West of Scotland presented with sharp nonradiating central chest pain, not positional in nature, with acute onset after co***ne usage hours earlier. In the field on first medical attendance, the patient was diaphoretic, agitated, cool to touch, and in an early state of clinical shock with blood pressure 79/58 mm Hg and heart rate 120 beats/min. Temperature was 36.8 °C, and respiratory rate was 20 breaths/min. Cardiac examination revealed no rub or murmur; the jugular venous pressure was elevated; lung fields were clear. Electrocardiogram showed a global pattern of ST-segment elevation https://bit.ly/3Y4R6VC

AbstractBackgroundWe report a case of hemorrhagic pericardial effusion with tamponade, secondary to myocardial injury by a hypodermic needle lost during narcotics injection some months prior.Case S...

12/20/2025

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12/20/2025

Evolving role of cardiac imaging in heart transplant recipients? Cardiac PET and CT can rule out coronary artery vasculopathy with high accuracy and inform prognosis in heart transplant recipients. Cardiac CT may be preferable at higher pre-test probabilities.

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12/19/2025

The 2025 ACC/AHA/Multisociety on adult congenital heart disease (ACHD) delivers updated, practice-changing recommendations for caring for a diverse population, accounting for differences in anatomy, physiology, healing, and treatment response.

Explore the Guideline-at-a-Glance in to accelerate adoption in practice: https://bit.ly/4pRFGAE

12/18/2025

🫀🔬 Anthracycline-induced cardiomyopathy (AIC) may be driven by aberrant extracellular signal–regulated kinase (ERK) activation. In a zebrafish AIC model, partial ERK inhibition was protective 🛡️, while excessive blockade worsened cardiotoxicity ⚠️. Targeting ERK could help treat AIC—but dose matters💊

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12/18/2025

The ACC and AHA, along with several other leading medical associations, have issued a new guideline for adult congenital heart disease, updating recommendations for monitoring, counseling, and treatment based on evidence from research published between 2017-2024 and replaces the previous guidance issued in 2018.

Get the details in : https://bit.ly/3Y4KM0d

12/17/2025

With the U.S. FDA approving a growing number of products that can perform quantitative coronary plaque analysis (QCPA), a new ACC Scientific Statement provides consensus recommendations on the appropriate use of QCPA in clinical practice.

The statement, published in and led by Chair Y.S. Chandrashekhar, MD, FACC, and Vice Chairs Ron Blankstein, MD, FACC, and Leslee J. Shaw, PhD, FACC, was developed by a panel of experts convened by the College to develop guidance for cardiovascular clinicians and imagers. It focuses on clinical indications, methods for interpretation and reporting, standardization, and future research directions.

Get the details: https://bit.ly/3MRSd8x

12/17/2025

A new ACC Scientific Statement on the management of peripheral artery disease (PAD) in adults with diabetes adds context to the 2024 ACC/AHA Lower Extremity PAD Guideline and "emphasizes a modern, evidence-based approach to care" starting with screening and advancing through treatment.

The statement, published in and led by Writing Group Chair Sandeep R. Das, MD, MPH, FACC, provides specific evidence-based consensus recommendations for screening, diagnosis and management of PAD in this patient population, which is at higher risk for cardiovascular events and amputations. The authors note that screening for PAD is "reasonable" for asymptomatic adults with diabetes and other risk-enhancing factors like smoking, diabetes duration, foot complications, age (older than 65 years), etc.

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12/16/2025

In families with hereditary ATTR, cascade genetic screening identified a median of two carriers per proband, enabled earlier diagnosis & therapy initiation. However, one-third of at-risk relatives remained untested, highlighting the need to strengthen family screening strategies.

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Graphical Abstract

12/16/2025

Peak frequencies (PFs) at macro–re-entrant atrial tachycardia (MRAT) termination sites are substantially higher than global atrial PFs, supporting the potential of PF mapping as an effective tool for identifying critical isthmuses in MRAT ablation procedures.

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12/15/2025

Kidney function remains a strong prognostic factor in older MI patients. Physiology-guided complete revascularization is effective regardless of renal function and may provide greater absolute clinical benefit in patients with chronic kidney disease due to their elevated baseline risk.

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12/15/2025

The analysis of 61 STEPS surveys and DHS in 37 countries highlights that the burden of remains substantial, the rates of treatment and control are alarmingly low, and stresses that the doubling of hypertension cases over the last 2 decades represents a major threat for the already fragile health infrastructures in the WHO AFRO. https://bit.ly/4rZOLsv