02/18/2026
Vagus nerve stimulation (VNS) is an emerging tool for managing inflammatory flares because the vagus nerve plays a key role in regulating the body’s “rest and digest” response and calming the immune system.
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Through what’s known as the cholinergic anti-inflammatory pathway, activation of the vagus nerve can help reduce the production of pro-inflammatory cytokines, potentially lowering systemic inflammation.
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While implantable VNS devices are used in certain medical conditions, many people can support vagal tone naturally through practices like slow diaphragmatic breathing, humming or singing, cold exposure, meditation, and gentle exercise.
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By improving nervous system balance and shifting the body out of chronic stress mode, vagus nerve stimulation may help decrease the frequency or intensity of inflammatory flares as part of a broader, personalized treatment strategy.