Jessi Grajczyk D.O.

Jessi Grajczyk D.O. Dr. Jessi Grajczyk D.O.

Physician & Women’s Health Expert
Double Board-Certified in OBGyn (FACOG) and Functional Medicine (IFMCP)
Functional Medicine practitioner focused on treating the underlying causes for sustainable healing and long-term wellbeing.

02/16/2026

Part 11: Can hormones be supported through diet?

Absolutely — nutrition, genetics, and lifestyle all play a role in how your body produces, metabolizes, and responds to hormones.

Emerging research continues to show that personalized nutrition and targeted supplementation can support hormone balance, longevity, and overall health. Tools like advanced genetic testing help us better understand:
• which foods may best support your body
• which supplements may be most effective
• what labs are most meaningful for you
• how to reduce long-term risks of chronic disease

Because hormone health isn’t one-size-fits-all — it’s individualized medicine.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

LongevityMedicine

02/14/2026

Part 10: Why more women may need HRT today

A century ago, hormone replacement therapy wasn’t even an option — but our environment and lifestyles looked very different too.

Today, many women are navigating:
• higher environmental toxin exposure
• chronic stress and fast-paced lifestyles
• adrenal fatigue from constant demands
• declining ovarian hormone production during perimenopause/menopause

Ideally, the adrenal glands help buffer hormonal transitions — but when they’re already stressed, symptoms can feel more intense. Thoughtfully prescribed hormone therapy can sometimes help bridge that gap and support overall balance.

As always, hormone care should be personalized, evidence-informed, and guided by your unique symptoms and goals.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

WomensHealth RootCauseCare

02/10/2026

Dr. Jessi on Hormone Replacement Therapy — Part 9: Estrogen & Cancer Risk

There’s still a lot of confusion around estrogen therapy and cancer risk. Current research continues to evolve, and some data suggest estrogen therapy — especially when individualized and appropriately timed — may not increase cancer risk and, in certain contexts, may even have protective effects.

That’s why personalized evaluation, proper testing, and working with a knowledgeable provider matter. Hormone therapy should never be one-size-fits-all — it’s about balance, timing, and your unique physiology.

Have questions about HRT or perimenopause symptoms? We’re here to help you navigate it with clarity and confidence.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

BioidenticalHormones RootCauseHealing

02/09/2026

Dr. Jessi on Hormone Replacement Therapy — Part 8: Why we don’t always start with estrogen

A common surprise: during perimenopause, we often don’t start with estrogen first.

Why? Many women are already relatively estrogen dominant while progesterone and testosterone are declining. So the first step is often:
✔ supporting progesterone
✔ balancing testosterone
✔ stabilizing symptoms before adding estrogen

Then, as cycles become irregular or symptoms progress (aka when the ovaries start “retiring”), estrogen support may be added thoughtfully to restore balance.

Hormone therapy isn’t one-size-fits-all — timing, symptoms, and testing all matter. Personalized care = better outcomes.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

WomensHealth RootCauseCare

01/27/2026

Dr. Jessi on Hormone Replacement Therapy — Part 7

Hot flashes get all the attention—but they’re only part of the picture.

Perimenopause and menopause can show up as:
• mood changes
• poor sleep
• body aches
• vaginal dryness
• feeling “off” without a clear reason

The key isn’t guessing—it’s testing.
Urine hormone testing (like the DUTCH test) shows how your body is actually metabolizing hormones, not just what your levels are on paper.

That insight allows us to:
✔ personalize food and supplement support
✔ improve hormone safety
✔ tailor care to your unique biology

This is what individualized, functional medicine looks like—no one-size-fits-all hormone plans.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

PersonalizedCare Women’sHealth

01/25/2026

HRT Part 6 - What happens during perimenopause?

Perimenopause isn’t random — it’s hormonal chaos with a reason.

Progesterone and testosterone tend to steadily decline, while estrogen fluctuates up and down. That imbalance often leads to estrogen dominance, which explains why so many women experience:
• mood swings
• irregular or heavy periods
• unpredictable cycles
• feeling “hormonal” or unlike themselves

And here’s the key takeaway: perimenopause doesn’t have an age requirement.
Some women notice symptoms in their mid-30s, others closer to 50. It’s not about the number — it’s about the symptoms.

This is why having an informed conversation with a provider who understands hormone physiology matters. Early guidance = better outcomes.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

’sHealth FunctionalMedicine RootCauseCare

01/22/2026

Dr. Jessi on Hormone Replacement Therapy — Part 5

This is where timing becomes everything.

When estrogen is started too late, after many years without hormonal support, the risk profile changes. Women naturally experience heart disease later than men in part because estrogen is protective. But if hormone therapy is initiated around age 63—after more than a decade post-menopause—there may already be plaque buildup in the arteries, which can increase cardiovascular risk.

This insight from the WHI helped shape what we now understand:
👉 Hormone therapy works best when started earlier, closer to menopause or during perimenopause.

The goal isn’t fear—it’s personalized, informed care based on physiology and timing, not outdated one-size-fits-all conclusions.

If you’ve been confused by mixed messages about HRT, you’re not alone—and the science has evolved.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

’sHeartHealth FunctionalMedicine RootCauseHealing

01/21/2026

Hormone Replacement Therapy — Part 4

What we’ve learned since the WHI is this: many women in that study were started on hormones too late. Today, the data shows that beginning hormone replacement therapy earlier—during perimenopause, when symptoms start—leads to better outcomes and lower risk.

Hot flashes, sleep disruption, mood changes, brain fog, weight shifts—these aren’t signs to “just push through.” They’re signals. And when addressed at the right time, hormone therapy can be both protective and empowering.

The takeaway?
👉 Earlier, personalized hormone support = better long-term health.

If you’re experiencing perimenopausal symptoms and wondering when to start the conversation, now is a great time.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

FunctionalMedicine RootCauseHealing

01/20/2026

Hormone Replacement Therapy — Part 3

Not all hormones are created equal.

In this clip, Dr. Jessi breaks down one of the most important distinctions in HRT:
👉 Bioidentical vs. synthetic hormones

Bioidentical hormones mirror the estrogen and progesterone your body naturally makes—allowing for gentler, more physiologic support. Synthetic versions often contain additives and dyes that can increase inflammation and may carry higher risk.

This is why how and what you prescribe matters just as much as if you prescribe.
Hormone care should be evidence-based, individualized, and rooted in safety—not outdated fear.

If you’ve been told “HRT isn’t safe” but never learned the difference… this conversation is for you.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

’sHealth RootCauseHealing Perimenopause MenopauseCare

01/19/2026

If you feel confused about hormones… you’re not imagining it.

Many women receive conflicting advice from different providers—especially when it comes to hormone replacement therapy.

Some clinicians were trained on outdated data. Others are hesitant due to fear or lack of education. And the result? Women left unsure of who to trust.

You deserve clarity. You deserve evidence-based care. And you deserve a provider who takes the time to individualize your treatment.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

01/18/2026

✨ Dr. Jessi on HRT (part 1) ✨

Hormone Replacement Therapy (HRT) isn’t one-size-fits-all. It can include pills, patches, injections, or creams—and may use estrogen, progesterone, and/or testosterone, depending on your needs.

For years, the WHI (Women’s Health Initiative) study caused fear and hesitation around HRT. But what many don’t realize? That data was flawed—and it held women back from therapies that can be truly life-changing.

Today, evidence-based providers are helping set the record straight. When appropriately prescribed and individualized, HRT can support:
• Energy & mood
• Bone & heart health
• Brain function
• Metabolic and overall quality of life

💬 “My goal is to get the truth out there—so women can make informed, empowered decisions about their hormones.”

If you’ve been told HRT is “dangerous” or “not for you,” it may be time for a deeper conversation.

📍 Plymouth, MN
🌐 DrJessiDO.com
📞 612-245-5665

Perimenopause MenopauseCare RootCauseHealing EvidenceBasedMedicine

01/15/2026

Elimination diet vs. food sensitivity testing — what’s the difference? 🤔🍽️

Dr. Jessi breaks it down
✨ An elimination diet is more general. We remove common triggers like gluten, dairy, eggs, soy, corn, and nightshades to see how your body responds overall.
✨ A food sensitivity test is personalized to you. It shows your specific reactions, but it does require commitment — removing flagged foods for 3 months if reactions are mild, or up to 6 months if they’re severe.
Both tools can be powerful — it’s all about finding what works best for your body.

🌐 Learn more or book at DrJessiDO.com
📍 Plymouth, MN | 📞 612-245-5665

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