03/23/2026
Most women think inflammation means swollen joints, body aches, or feeling sore after a long day.
But the kind of inflammation I see driving weight gain in women with Hashimoto’s and Graves’ is much quieter than that.
It is happening in the gut and immune system and it shows up as elevated antibodies long before it shows up as stubborn weight.
When the gut is inflamed, the immune system stays activated, and that changes how your body uses thyroid hormone and burns fat.
On top of that, your liver and bile are responsible for calming the gut (and therefore the immune system), converting hormones, and clearing them out when they are used by the cells.
If that system slows down, those hormones recirculate and create even more imbalance, which can make weight feel stuck no matter how little or how clean you eat.
This is why eating less and moving more often stops working for women in postpartum, perimenopause, or menopause with elevated antibodies AND swinging hormones that bog down the liver and bile flow.
And here’s the kicker:
When you start cutting more and more foods, it slows down bile flow, which your body needs to keep things moving out.
Less flow means more buildup, more immune activation, and more frustrating weight gain. (This is extra loud for women who have lost their gallbladder!)
The most helpful step is not cutting calories or spending hours in the gym.
It’s understanding what is actually triggering the inflammation in your body so you can work with it instead of against it.
If you want to see how this works and what to look for, click here to watch my antibodies class: https://www.thyroidbymissy.com/antibody-video