11/07/2025
A new study from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort shows that waist-to-hip ratio (WHR) significantly impacts cardiovascular risk linked to lipoprotein(a), meaning abdominal adiposity can amplify Lp(a)’s impact [PMID: 40081639].
For clinicians focused on longevity and cardiovascular health, it underscores two big takeaways: (1) measuring WHR adds nuance to Lp(a)-based risk stratification, and (2) it reminds us that targeted lifestyle and body composition interventions still matter, even in a “high genetic risk” patient.
Source: https://www.sciencedirect.com/science/article/pii/S0033062025000301