02/06/2026
https://www.facebook.com/share/p/1BnB8E1nmM/?mibextid=wwXIfr
When you eat may matter as much as what you eat.
A new 2025 review in Current Obesity Reports takes a deep look at time-restricted eating (TRE) and what it’s really doing under the hood.
From a functional medicine lens, the most important takeaway is about circadian biology.
TRE appears to:
• Resynchronize peripheral clocks (liver, muscle, gut, adipose tissue)
• Improve mitochondrial signaling and metabolic flexibility
• Reduce inflammatory signaling
• Support autophagy and cellular repair
• Favorably influence the gut microbiome
Clinically, TRE performs about as well as calorie restriction for weight loss, without calorie counting, which matters for adherence. More importantly, it reinforces a core FxMed principle: metabolism is rhythmic, and timing is a therapeutic lever.
This aligns closely with how I think about metabolic timing, resilience, and aging biology in Younger You, not extremes, but intelligent signaling.
https://doi.org/10.1007/s13679-025-00609-z
Funding & disclosures: Open-access funding provided by UniversitĂ degli Studi di Roma Tor Vergata (CRUI-CARE Agreement). No external funding. Authors report no competing interests.