13/10/2025
🟢Anticoagulants
- **M.O.A**: Inhibit blood clotting factors, preventing thrombus formation.
- 🛑 **Targeted Coagulation Factors**:
- **Factor II (Thrombin)**
- **Factor Xa**
- **Factors VII and IX**.
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- *Examples*:
- 💊 **Warfarin**: A vitamin K antagonist that inhibits the synthesis of vitamin K-dependent clotting factors.
- 💊 **Apixaban**: A direct Factor Xa inhibitor used for stroke prevention and the treatment of deep vein thrombosis and pulmonary embolism.
- 💊 **Rivaroxaban**: Another direct Factor Xa inhibitor, commonly used for similar indications as apixaban.
- 💊 **Dabigatran**: A direct thrombin inhibitor used for atrial fibrillation and the treatment of deep vein thrombosis and pulmonary embolism.
- 💉 **Heparin**: Unfractionated heparin that enhances the activity of antithrombin to inhibit thrombin and Factor Xa.
- 💉 **Enoxaparin**: A low molecular weight heparin that primarily inhibits Factor Xa.
- 💉 **Fondaparinux**: A synthetic pentasaccharide that selectively inhibits Factor Xa.
✅ - **Uses**: Treatment and prevention of conditions such as **Deep Vein Thrombosis (DVT)**, **Pulmonary Embolism (PE)**, and stroke prevention.
🔴Antiplatelets
- **M.O.A**: Prevent platelet aggregation, reducing the risk of thrombus formation.
- **Examples**:
- 💊 **Aspirin**: Inhibits Cyclooxygenase (COX).
- 💊 **Clopidogrel**: Blocks ADP receptors on platelets.
- ✅ **Uses**: Commonly used to prevent **Myocardial Infarction (MI)** and stroke, especially in high-risk patients.
الفرق بينهما باختصار
- 🟢 **Anticoagulants**: Target coagulation factors (e.g., II and Xa) to prevent thrombus formation throughout the body.
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- 🔴 **Antiplatelets**: Focus on preventing platelet aggregation at the site of injury.
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مذكرة دواء | pharma Note
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