11/11/2025
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A five-year follow-up of a psilocybin-assisted therapy study found that two-thirds of participants with Major Depressive Disorder were still in remission five years after treatment, with marked improvements in well-being measures.
While multiple factors may have influenced the results and many participants sought additional treatment during that period, the rapid and sustained response sets it apart from conventional approaches.
βSome of the most debilitating aspects of depression are people isolating and withdrawing from things that are important to them. Despite some of those symptoms coming back, they found they werenβt experiencing those same levels of impairment β that really speaks to the potential for some people that this treatment might catalyse future positive effects when theyβre going through depression.β β lead author Alan Davis
π Five-year outcomes of psilocybin-assisted therapy for Major Depressive Disorder β Davis et al., 2025
ποΈ Full article: https://akjournals.com/view/journals/2054/aop/article-10.1556-2054.2025.00461/article-10.1556-2054.2025.00461.xml
Interview with lead author in the Ohio State News: https://news.osu.edu/depression-remission-endures-5-years-after-psilocybin-trial/