02/08/2025
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Leptin, Not Just Insulin, May Hold the Key to Diabetes Treatment
A decade-old discovery is gaining new attention as researchers confirm that leptin, a hormone tied to energy balance, can reverse diabetic ketoacidosis without insulin.
The brain’s misinterpretation of low leptin levels initiates a dangerous metabolic response, leading to hyperglycemia and elevated ketones.
When leptin was administered directly to diabetic rodents, it stabilized their blood sugar long-term.
This suggests the brain—not just the pancreas—plays a pivotal role in regulating diabetes.
Scientists now believe targeting brain pathways could lead to more effective treatments.
Human trials are on the horizon, opening the door to a new paradigm in diabetes management.
