Wits RHI is a renowned African institute in a world-class African University tackling the continent's health challenges through science and innovation.
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Wits RHI addresses some of the greatest public health concerns affecting our region, focusing on HIV/TB, sexual and reproductive health, and vaccine-preventable diseases.
29/01/2026
Men deserve safe, judgment-free spaces to ask questions and take charge of their health. Self-Cav empowers men with accurate, confidential information on sexual and reproductive wellbeing helping them make informed choices with confidence. With compassionate, reliable guidance always at hand, Self-Cav supports men to prioritise their health. Text CavWitsRHI to 087 373 1548 to start your journey today. Audere
22/01/2026
📢 New Prevention Research from Wits RHI. Can one pill help protect women from both & unplanned pregnancy? Our latest study, published in the JAIDS Journal of Acquired Immune Deficiency Syndromes, explores women’s adherence, preferences, and experiences with a dual prevention pill in Johannesburg. The findings highlight a key message: choice matters when it comes to for women. Read the full study: https://bit.ly/45qU2zL
22/01/2026
From exploring prevention options to asking sensitive questions in a safe, private space, Self-Cav offers compassionate, reliable answers designed to empower you. With privacy and care at the centre of every interaction, you can feel supported at every step of your health journey. Text the word CavWitsRHI to 0873731548 to join. Audere
19/01/2026
📢Through Their Lens: Heat, Pregnancy & Resilience. Wits RHI researchers explored how pregnant and postpartum women in a South African township experience and cope with extreme heat. Their study uncovers daily challenges, coping strategies, and the urgent need for climate-resilient maternal health solutions. Full article: https://bit.ly/3Nqimf4
19/01/2026
Health is a journey, powered by research, guided by purpose.
16/01/2026
🌟 : Prof Helen R ees 🌟 Our Executive Director, Professor Helen Rees, is featured in The Dolphin Murray Edwards College Cambridge Alumnae Spotlight as one of three global health champions. Her lifelong dedication to advancing health, promoting equity, and leading in science continues to inspire around the globe. Read more here 👉 https://bit.ly/4qk🌟 : Prof Helen Rees 🌟 Our Executive Director, Professor Helen Rees, is featured in The Dolphin Murray Edwards College Cambridge Alumnae Spotlight as one of three global health champions. Her lifelong dedication to advancing health, promoting equity, and leading in science continues to inspire around the globe. Read more here 👉 https://bit.ly/4qk0UqZ Wits - University of the Witwatersrand Wits Faculty of Health Sciences
13/01/2026
Experience a new kind of care that prioritises your comfort, empowerment, and access to information. Learn more about your AI health companion today. Text the word CavWitsRHI to 0873731548 to start your journey today.
08/01/2026
It’s free, judgment-free, and always here for you. Whether you’re looking for general wellbeing guidance or clear, accurate sexual and reproductive health information, Self-Cav is your trusted companion. Text the word CavWitsRHI to 0873731548 to start the conversation.
24/12/2025
With easy access to trusted answers, Self-Cav helps you navigate your health journey with confidence and clarity. Whether you have questions about your wellbeing, need support understanding your healthcare options, or want a safe space to learn more about your health, Self-Cav is here to support you every step of the way. Text the word CavWitsRHI to 0873731548 to start your journey today.
18/12/2025
Healthcare has never been this friendly, convenient, or personal. Self-Cav is your trusted AI health companion, designed to guide and support you every step of the way. With user-centred features that simplify your experience, Self-Cav helps you access reliable information, ask health-related questions, and receive personalised support anytime, anywhere. Text the word CavWitsRHI to 0873731548 to join.
17/12/2025
📍Eleven clinical trials poised to transform medicine in 2026. Nature Medicine has highlighted the top trials shaping the future of healthcare, from breakthrough vaccines to innovative treatments. We’re proud to share that Wits RHI Prof Lee Fairlie, Director of Maternal and Child Health, is featured for her work on the M72/AS01 tuberculosis vaccine trial, a key study in her portfolio.
Read more: https://bit.ly/3XZGZ4d
17/12/2025
📢Breaking Global Health News. We are proud to share that the U.S. FDA has approved Nuzolvence® (zoliflodacin), the first new oral antibiotic for gonorrhoea in decades. Wits RHI Prof Sinead Delany-Moretlwe says: "Gonorrhoea can have a devastating impact on women in particular… Having a single-dose, oral treatment like this could be a game-changer for gonorrhoea control." contributed to this global Phase 3 trial, highlighting our commitment to innovative public health solutions. Read More: https://bit.ly/49lrE3p
Wits - University of the Witwatersrand Wits Faculty of Health Sciences
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Wits RHI was founded in 1994 by Prof Helen Rees. In consultation with the democratically elected South African government, she founded the Reproductive Health Research Unit (RHRU) at the University of the Witwatersrand.
Recognising that the old health research agenda did not address the needs of all South Africa’s citizens, a new research agenda was developed aimed at shaping new health policies. As co-author of the Maternal, Child and Women’s Health policy, Prof Rees established RHRU as a research and training institution focused on sexual and reproductive health and later HIV as an emerging epidemic at that time. The work then combined clinical, epidemiological, health systems and behavioural research to help formulate national health policy.
A small RHRU team worked from Baragwanath Hospital in Soweto, supported by grants from the Kaiser Foundation and the UK’s Department for International Development. The RHRU’s partnering organisations included the Medical Research Council, and international agencies such as Family Health International. In 2005 the organisation moved from Soweto to Hillbrow in inner city Johannesburg as it expanded its work to include a much closer relationship with both the City of Johannesburg and the Gauteng Department of Health.
The RHRU’s early research focused on contraceptive access, microbicide development, safe abortion, and female condom development. Key to this early work was the establishment of partnerships with local communities where the Unit’s work was taking place.
The ethos of the organisation was, and remains, to place its clients/ beneficiaries at the centre of its work and this was achieved primarily through the establishment of community advisory boards.
The RHRU/City of Johannesburg partnership expanded to the Gauteng Health Department and the private sector, and the vision of the Hillbrow Health Precinct (HHP) was born, driven by the RHI. This world-first project took derelict heritage buildings in the abandoned Hillbrow Hospital and restored them for community-based clinical and social services, with integrated state of the art clinical and laboratory research facilities utilised by RHRU.
In 2010, the RHRU was designated an Institute by Wits University in recognition of its research outputs and international standing, and the Wits Reproductive Health and HIV Institute (Wits RHI) was established.
Wits RHI has utilised the research base offered by the HHP and the inner city, to develop a comprehensive research agenda that spans clinical, epidemiological, behavioural and health systems research, and implementation science.
To date Wits RHI has estalished a national network of research sites across the country. Wits RHI now has more than 74 grants under management. Funding is sourced both internationally and locally, and includes substantive grants from the Department of Health, National Institutes of Health, Bill & Melinda Gates Foundation, European Union, the World Health Organization (WHO), United States Agency for International Development (USAID), Unitaid and the President’s Emergency Plan for AIDS Relief (PEPFAR).
The Institute now has a staff complement of more than 1400 staff, with 25 staff who are at researcher level or above.