20/04/2026
We often tell patients:
“Do your exercises -they’ll help you heal.”
But how?
This paper (see below) gives a powerful answer:
👉 Load changes tissue.
Through a process called Mechanotransduction, mechanical stress is converted into cellular activity that drives repair and remodelling. 
In simple terms:
Movement → cellular signalling → protein synthesis → tissue adaptation
The authors even reintroduce the term “mechanotherapy” - using exercise as a treatment to stimulate healing, not just improve fitness. 
And importantly:
• Muscle responds to load by activating growth pathways
• Controlled loading improves alignment and regeneration
• Too little load? → tissue loss
• Appropriate load? → stronger, better tissue 
Which raises a key clinical question:
Are we prescribing exercise as a habit…
or as a targeted biological stimulus?
At Le Roux and Oosthuizen Biokineticists we aim for evidence based prescription.
Because exercise isn’t just something we give patients…
It’s one of the most powerful treatment tools we have. 💪🧠
*See full article*
247.full.pdf
