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Researchers have found that when you exercise, your body releases microscopic sacs called extracellular vesicles into the bloodstream, and these may be a key part of how exercise stimulates the birth of new brain cells. In experiments with mice, scientists collected vesicles from animals that had run freely and injected them into sedentary mice. The recipients showed about a 50 percent increase in new neurons in the hippocampus, the brain area important for memory and learning. These vesicles carry proteins, lipids and genetic material that appear to trigger neural stem cells to divide and form neurons.

What makes this discovery exciting is that the vesicles alone, without actual physical activity, were sufficient to spark increased neurogenesis. The study suggests that tissues like muscle and liver release these vesicles during exercise, and they travel through the body and influence the brain. It is not yet clear exactly which molecules inside the vesicles are doing the job or how they cross into the brain.

Research Paper 📄
DOI: 10.1016/j.brainres.2025.150003

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